Unit
Medizinisches Forschungszentrum
MFZ · Management
Systembiologische Untersuchungen zur molekularen Charakterisierung der Mikroumgebung in Lungentumoren
Jul 1, 2012Das Thema des geplanten Forschungsprojekts sind systembiologische Untersuchungen zur molekularen Charakterisierung der Mikroumgebung in Lungentumoren. Lungenkrebs ist eine der häufigsten Todesursachen in den industrialisierten Ländern. Die meisten Pa...
Fundamental Research - Jul 1, 2012 - Jun 30, 2014
Completed
Project leader: Ludewig Burkhard, Brutsche Martin
Members: Franzini Anca, Tarantino Ignazio
Systems biology approach to moleculary characterize the lung cancer microenvironment
Jul 1, 2012Tumor cells display distinct genetic alterations that permit their unrestricted growth. In contrast, stromal cells that provide the growth scaffold and nutrients for the tumor, most likely exhibit universal signatures that determine their function. T...
Fundamental Research - Jul 1, 2012 - Jun 30, 2014
Completed
Project leader: Ludewig Burkhard
Members: Franzini Anca, Bocharov Gennady
Funktionelle Charakterisierung und therapeutische Nutzung des mesenchymalen Tumorstromas
Mar 1, 2012Das Thema des geplanten Forschungsprojekts ist die funktionelle Charakterisierung und therapeutische Nutzung des mesenchymalen Tumorstromas. Neben den eigentlichen Tumorzellen, die unterschiedliche genetische Veränderungen aufweisen, finden sich im T...
Fundamental Research - Mar 1, 2012 - Feb 28, 2014
Completed
Project leader: Ludewig Burkhard
Members: Onder Lucas
Stromal Cell - Immune Cell Interactions in Health and Disease
Jan 1, 2012STROMA is an Initial Training Network promoting the study of stromal cell – immune system interactions during stroma development and function in health and disease. In STROMA we have bought together world leading experts from academia and industry in...
Fundamental Research - Jan 1, 2012 - Jan 31, 2015
Completed
Project leader: Ludewig Burkhard
Members: Cheng Hung-Wei, Novkovic Mario
Stroma Cell- Immune Cell Interactions in Health and Disease
Jan 1, 2012STROMA is an Initial Training Network promoting the study of stromal cell – immune system interactions during stroma development and function in health and disease. In STROMA we have bought together world leading experts from academia and industry in...
Fundamental Research - Jan 1, 2012 - Dec 31, 2015
Completed
Project leader: Ludewig Burkhard, Tarte Karin, Sixt Michael, Dzionek Andrzej, Mueller Christopher George, Hazel Jones, Giese Christoph, Cupedo Tom, de Boer Jan, Kaye Paul, Veiga Fernandes Henrique
Members: Novkovic Mario, Cheng Hung-Wei, Mörbe Urs
Polyvalent vaccine against Salmonellosis
Nov 1, 2011The major aim of this project is to generate a polyvalent vaccine candidate using microencapsulates Salmonella typhi proteins for oral administration. To this end, the laboratory in Mexico will produce sufficient amounts of S. typhi porins for encaps...
Fundamental Research - Nov 1, 2011 - Apr 30, 2013
Completed
Project leader: Ludewig Burkhard
Members: Pérez Shibayama Christian Ivan, Gil Cruz Cristina
Mechanisms of antibody-mediated protection against virus-induced inflammatory demyelination
Jul 1, 2011Background: The epidemiology of multiple sclerosis (MS) suggests that environmental factors such as infections with coronaviruses critically determine the risk for this chronic demyelinating disease. Infection of the CNS with neurotropic mouse corona...
Fundamental Research - Jul 1, 2011 - Jun 30, 2013
Completed
Project leader: Gil Cruz Cristina, Ludewig Burkhard
Members: Thiel Volker
Analyse der T-Zellfunktion bei Virus induzierter Chorioretinitis
Jul 1, 2010Die Chorioretinitis ist eine häufig zu visuellen Wahrnehmungsstörungen (Sehbehinderung oder gar Erblindung) führende Erkrankung. Ursache der sich flächenhaft ausdehnenden und rasch progredienten Erkrankung der Netzhaut sind oftmals virale Infektionen...
Fundamental Research - Jul 1, 2010 - Jun 30, 2013
Completed
Project leader: Ludewig Burkhard
Members: Cupovic Jovana
Role of T helper cells in cardiovascular immunopathological disease
Apr 1, 2010Chronic inflammatory reactions directed against cells within the vascular wall or the myocardium are key elements in the pathogenesis of cardiovascular diseases. Although myocarditis is a rather frequent cause of death in young adults, the lack of kn...
Fundamental Research - Apr 1, 2010 - Mar 31, 2013
Completed
Project leader: Ludewig Burkhard
Members: Nindl Veronika
Impact of immune regulation on virus-induced chronic CNS inflammation and demyelination
Aug 1, 2009Background: Multiple sclerosis (MS) is an important disease affecting young adults. Epidemiological studies indicate that this disease critically depends on environmental factors, including infectious agents. It appears that infections with a variety...
Fundamental Research - Aug 1, 2009 - Sep 30, 2009
Completed
Project leader: Ludewig Burkhard, Thiel Volker
Members: Cervantes-Barragan Luisa, Cupovic Jovana
Examining the function of lymphoid organ structure during antiviral immune responses using microscopic and mesoscopic imaging
Jun 1, 2009The adaptive immune system protects us from infectious viruses and other microbes. Cells of the adaptive immune system ‐ lymphocytes and antigen‐presenting cells (APC) ‐ are highly organized in strategic tissue locations throughout...
Fundamental Research - Jun 1, 2009 - Jul 31, 2012
Completed
Project leader: Ludewig Burkhard
Members: Scandella Elke, Onder Lucas
TOLERAGE: Normalisation of immune reactivity in old age – from basic mechanisms to clinical application
Apr 1, 2008Reconstitution of normal immune function in old age is generally based on boosting the response against foreign antigens, e.g. infectious microorganisms. Our focus, however, will be to normalise immune reactivity by correcting the immune dysregulati...
Fundamental Research - Apr 1, 2008 - Sep 30, 2012
Completed
Project leader: Ludewig Burkhard, Thiel Volker
Members: Cervantes-Barragan Luisa, Eugster Karin
Entwicklung einer Coronavirus basierten Multigenvakzine zum Schutz gegen Tumorerkrankungen
Jan 1, 2008Krebszellen produzieren antigenetische Zielstrukturen, die sie für einen Angriff durch spezifische Immunzellen sensibilisieren. Die effektivste Waffe des Immunsystems gegen Tumorzellen sind zytotoxische T-Zellen. Die effiziente Aktivierung dieser Kil...
Fundamental Research - Jan 1, 2008 - Dec 31, 2009
Completed
Project leader: Ludewig Burkhard, Thiel Volker
Members: Makia Divine, Nussbacher Monika
Impact of immune regulation on virus-induced chronic CNS inflammation and demyelination
Jan 1, 2008Background: Multiple sclerosis (MS) is an important disease affecting young adults. Epidemiological studies indicate that this disease critically depends on environmental factors, including infectious agents. It appears that infections with a variety...
Fundamental Research - Jan 1, 2008 - Dec 31, 2008
Completed
Project leader: Ludewig Burkhard
Members: Cervantes-Barragan Luisa, Eugster Karin
Role of professional and non-professional antigen presenting cells in cardiovascular immunopathological disease
Apr 1, 2007The importance of chronic inflammatory processes in the pathogenesis of cardiovascular diseases is now widely recognized. Atherosclerosis and autoimmune myocarditis are prototypical diseases illustrating the detrimental effects of constant immune act...
Fundamental Research - Apr 1, 2007 - Mar 31, 2010
Completed
Project leader: Ludewig Burkhard
Members: Eugster Karin, Nindl Veronika
Multiepitop Imfpung von Grad III/IV Melanompatienten mit dendritischen Zellen: Bedeutung von Peptidaffinität und -dichte für die optimale Generierung von tumorspezifischen zytotoxischen T-Lymphozyten
Jan 1, 2007Die immunologische Forschung der letzten Jahre hat deutlich gemacht, dass Krebszellen Zielstrukturen, sogenannte Antigene, produzieren, die sie für einen Angriff durch spezifische Immunzellen sensibilisieren. Die effektivste Waffe des Immunsystems ge...
Clinical Studies - Jan 1, 2007 - Dec 31, 2009
Completed
Project leader: Ludewig Burkhard, Gillessen Sommer Silke, Cerny Thomas
Members: Maier Reinhard, Templeton Arnoud
Immunpathologie der Virus induzierten Chorioretinitis
Jan 1, 2007Die Chorioretinitis ist eine häufig zu visuellen Wahrnehmungsstörungen (Sehbehinderung oder gar Erblindung) führende Erkrankung. Ursache der sich flächenhaft ausdehnenden und rasch progredienten Erkrankung der Netzhaut sind oftmals virale Infektionen...
Fundamental Research - Jan 1, 2007 - Dec 31, 2009
Completed
Project leader: Ludewig Burkhard
Preventing autoimmune myocarditis through cardiac myosin-specific tolerance
Jan 1, 2007The exact pathological basis of human myocarditis has not yet been sufficiently clarified and therefore, the appropriate treatment has remained a major clinical problem. Assuming that immunopathological damage contributes to the inflammatory nature o...
Fundamental Research - Jan 1, 2007 - Dec 31, 2009
Completed
Project leader: Ludewig Burkhard
Members: Nindl Veronika, Maier Reinhard
AIDS-CoVAC: Generation of a coronavirus-based multigene AIDS vaccine and evaluation in a preclinical SIV model
Dec 1, 2006Coronaviruses spread via mucosal surfaces and can infect dendritic cells. These features and their exceptional transcription strategy make them extremely promising candidate vaccine vectors to overcome known problems of current HIV vaccine approaches...
Fundamental Research - Dec 1, 2006 - May 31, 2009
Completed
Project leader: Ludewig Burkhard, Thiel Volker
Members: Eugster Karin, Cervantes-Barragan Luisa, Makia Divine
Coronavirus-based multigene HIV vaccine vectors
Jul 1, 2005The specific aim of this application is to provide the proof-of-principle that coronavirus vectors can indeed induce protective antiviral humoral and cellular immune responses in vivo. To this end, we will generate mouse hepatitis virus (MHV) vectors...
Fundamental Research - Jul 1, 2005 - Jun 30, 2007
Completed
Project leader: Thiel Volker
Members: Ludewig Burkhard