Unit
Medizinisches Forschungszentrum
MFZ · Management
Dissecting the association of anti-microbiota antibodies and auto-reactive T-cells in cardiomyopathy– an exploratory research Project
Jan 25, 2018Prospective research project in which biological material is sampled from humans and health-related personal data is collected (HFV Art 6). To generate further scientific evidence for a potential role of crossreactive antimicrobial T and B cell respo...
Clinical Studies - Jan 25, 2018 - Aug 25, 2021
Completed
Project leader: Ludewig Burkhard
Members: Maeder Micha, Vetsch Susanne
Defining the identity and differentiation pathways of the immune-stimulating fibroblastic tumor stroma
Jan 1, 2018Lung cancer is the most frequent cause of death in cancer patients in industrialized countries. A particular property of non-small cell lung cancer is the composition of the tumor microenvironment (TME) with a very high proportion of stromal cells. W...
Fundamental Research - Jan 1, 2018 - Dec 31, 2021
Automatically Closed
Project leader: Ludewig Burkhard
Members: De Martin Angelina
Dissecting the association of the human palatine tonsil microbiome and HPV-driven oropharyngeal squamous cell carcinoma
Jan 1, 2017Oropharyngeal squamous cell carcinoma (OPSCC) can be caused by viral transformation of epithelial cells in the oropharynx such as high risk-human papilloma virus (HR-HPV). Importantly, the incidence of OPSCC has been increasing during the last decade...
Fundamental Research - Jan 1, 2017 - Dec 31, 2018
Automatically Closed
Project leader: Ludewig Burkhard
Members: Broglie Däppen Martina, Stöckli Sandro, Cupovic Jovana
Constructing accessory lymph nodes in situ for control of mammary carcinoma
Jul 1, 2016Lymph nodes (LNs) are situated at junctures of the blood vascular and the lymphatic system where antigens drain from peripheral tissues via afferent lymphatics. The decision whether and how immune responses against tumors are initiated and maintained...
Fundamental Research - Jul 1, 2016 - Jun 30, 2019
Automatically Closed
Project leader: Ludewig Burkhard
Members: Cupovic Jovana
Defining the origin of lymph node and Peyer's patch fibroblastic reticular cells at single cell resolution
Apr 1, 2016Secondary lymphoid organs such as lymph nodes (LNs) and Peyer’s patches (PPs) sample antigens from the body’s inner and outer surfaces and mediate optimal interaction of immune cells. These functions rely on the presence of specialized microenvironme...
Fundamental Research - Apr 1, 2016 - Mar 31, 2019
Automatically Closed
Project leader: Ludewig Burkhard
Members: Mörbe Urs, Pérez Shibayama Christian Ivan
Targeting breast cancer through manipulation of IL-7 producing tumor fibroblasts
Jan 1, 2016Breast cancer is by far the most frequent gynaecological cancer. Despite considerable advances in antitumor therapies during the last 15 years, metastatic and recurrent breast cancer is still incurable, indicating that the underlying pathogenesis of...
Fundamental Research - Jan 1, 2016 - Dec 31, 2017
Automatically Closed
Project leader: Ludewig Burkhard
Members: Bösch Maximilian
Role of activated fibroblastic stromal cells in relapsing-remitting experimental autoimmune encephalomyelitis
Oct 1, 2015Multiple Sclerosis (MS) is an inflammatory disease of the central nervous system (CNS) resulting in demyelination, axonal loss and consequential clinical impairment. In addition, the presence of meningeal inflammatory infiltrates in the progressive M...
Fundamental Research - Oct 1, 2015 - Nov 1, 2016
Automatically Closed
Project leader: Ludewig Burkhard
Members: Pikor Natalia
Blockade der Fibroblastenreifung zum Schutz vor autoimmuner Sehnerventzündung
Oct 1, 2015Optikusneuritis (Neuritis nervi optici, NNO) ist eine akute Entzündung des Sehnervs, die mit Symptomen wie Augenschmerzen und partiellem oder komplettem Sehverlust einhergeht. Die meisten Fälle der NNO sind auf multiple Sklerose (MS) als Grunderkrank...
Fundamental Research - Oct 1, 2015 - Sep 30, 2016
Automatically Closed
Project leader: Ludewig Burkhard
Members: Cupovic Jovana
Impact of omental fibroblastic stromal cells on the induction of anti-bacterial immunity
Oct 1, 2015Adaptive immune responses are induced within secondary lymphoid organs (SLOs) such as lymph nodes, spleen and Peyer’s patches. Structure and compartmentalization of SLOs is determined by fibroblastic stromal cells which built and maintain specialized...
Fundamental Research - Oct 1, 2015 - Sep 30, 2016
Automatically Closed
Project leader: Ludewig Burkhard
Members: Pérez Shibayama Christian Ivan, Mörbe Urs
Ontogeny and functional characterization of splenic fibroblastic reticular cells (FRCs) and their mesenchymal precursors during homeostasis, immune-activation and infection
Sep 1, 2015Secondary lymphatic organs (SLOs) such as the spleen provide specialized microenvironmental niches for the development and control of immune responses. Particular mesenchymal stromal cells known as fibroblastic reticular cells (FRCs) generate distinc...
Fundamental Research - Sep 1, 2015 - Aug 31, 2018
Automatically Closed
Project leader: Ludewig Burkhard
Members: Cheng Hung-Wei
"Mechanisms of Evasive Resitance in Cancer (MERiC)"
Nov 1, 2014-prospektive Beobachtungsstudie von Patienten mit HCC -Leberbiopsie vom Leberrundherd, Re-Biopsie bei Tumorprogression nach jeder Behandlung (TACE etc.) bis Behandlungsende HCC
Clinical Studies - Nov 1, 2014 - Nov 1, 2020
Automatically Closed
Project leader: Semela David
Members: Alfter Christine, Pérez Shibayama Christian Ivan
Prostatic Artery Embolization vs. conventional TUR-P in the Treatment of Benign Prostatic Hyperplasia: A prospective randomized trial
Feb 5, 2014
Clinical Studies - Feb 5, 2014 - Apr 5, 2023
Automatically Closed
Project leader: Engeler Daniel, Abt Dominik
Members: Schmid Hans-Peter, Hechelhammer Lukas, Patzl Sigrid, Lengwiler Daniel, Haile Sarah, Maier Reinhard, Schulz Thomas
Clinical evaluation of a polyvalent vaccine against Salmonella enterica in a phase I/II Study
Jun 1, 2013Salmonella enterica infections are an important global health problem with more than 20 million individuals suffering from enteric fever annually and more than 200’000 lethal cases per year. Although enteric fever can be treated appropriately with an...
Fundamental Research - Jun 1, 2013 - Dec 31, 2016
Automatically Closed
Project leader: Ludewig Burkhard, Vernazza Pietro
Members: Carreño Juan-Manuel
A randomized phase II trial of pertuzumab in combination with trastuzumab with or without chemotherapy, both followed by T-DM1 in case of progression, in patients with HER2-positive metastatic breast cancer
May 1, 2013The primary objective of this trial is to evaluate the efficacy in terms of overall survival (OS) at 24 months of a chemotherapy-free dual HER2-inbibition with trastuzumab and pertuzumab (first-line) followed by T-DM1 (second-line) and of a chemother...
Clinical Studies - May 1, 2013 - May 1, 2019
Automatically Closed
Project leader: Weder Patrik
Members: Thürlimann Beat, Ruhstaller Thomas, Maier Reinhard, Riniker Salome, Öhlschlegel Christian, Hasler-Strub Ursula
SAKK 22/10: A randomized phase II trial of pertuzumab in combination with trastuzumab with or without chemothera-py, both followed by T-DM1 in case of progression, in pa-tients with HER2-positive metastatic breast cancer
Apr 29, 2013In der vorliegenden Studie wird eine neue Strategie für die Behandlung des HER2-positiven metastasierenden Brustkrebses untersucht, bei der die Erstlinientherapie aus Herceptin® und Perjeta® besteht und somit chemotherapiefrei ist. Bei Fortschreiten...
Clinical Studies - Apr 29, 2013 - Jun 27, 2015
Automatically Closed
Project leader: Weder Patrik
Members: Ruhstaller Thomas, Hasler-Strub Ursula, Maier Reinhard, Öhlschlegel Christian, Riniker Salome, Kaelin Martin, Hochstrasser Andreas, Thürlimann Beat
Selection and education of heart-specific Th cells by thymic and lymph node stromal cells
Apr 1, 2013Myocarditis is a frequent disease in children and young adults that can precipitate lethal dilated cardiomyopathy (DCM). Since some heart antigens, such as the cardiac myosin heavy chain alpha (myhca) are not represented in the thymus, heart-specific...
Fundamental Research - Apr 1, 2013 - Mar 31, 2016
Completed
Project leader: Ludewig Burkhard
Members: Pérez Shibayama Christian Ivan, Bösch Maximilian, Gil Cruz Cristina
Systems biology approach to molecularly characterize the lung cancer microenvironment
Jan 1, 2013Lung cancer is the most frequent cause of death in cancer patients in industrialized countries. Most patients with advanced nonsmall cell lung cancer (NSCLC) do not respond to the current treatment schemes indicating that the basic mechanisms of tumo...
Fundamental Research - Jan 1, 2013 - Dec 31, 2014
Completed
Project leader: Ludewig Burkhard, Brutsche Martin
Members: Baty Florent, Novkovic Mario, Onder Lucas
Role CCR7-ligands in virus-induced chronic CNS inflammation and demyelination
Jan 1, 2013Background: Epidemiological studies indicate that onset and progression of multiple sclerosis (MS) critically depends on environmental factors, including infectious agents. Experimental infections with neurotropic viruses can precipitate MS-like path...
Fundamental Research - Jan 1, 2013 - Dec 31, 2013
Completed
Project leader: Ludewig Burkhard
Members: Gil Cruz Cristina, Cupovic Jovana
Imaging-based Systems Biology Analysis of Lymph Node Structure and Function in Viral Infection
Aug 1, 2012Our research plan includes three complementary subprojects, which are carried-out in a highly synergistic manner by the partners Dr. Stein (UBERN), Prof. Ludewig (KSSG) and Dr. Sharpe (CRG), respectively. The three subprojects address the following a...
Fundamental Research - Aug 1, 2012 - Jul 31, 2016
Automatically Closed
Project leader: Ludewig Burkhard
Members: Chai Qian, Gil Cruz Cristina
Systems immunological analysis of lymph node structure and function in viral infection
Aug 1, 2012Peripheral lymph nodes (PLNs) perform three central functions as a structural interface between the innate and adaptive immune systems: first, sentinel PLNs retain microbial‐derived antigen (Ag) from the periphery arriving via afferent lymphatic ves...
Fundamental Research - Aug 1, 2012 - Jul 31, 2016
Completed
Project leader: Ludewig Burkhard
Members: Chai Qian, Pérez Shibayama Christian Ivan, Gil Cruz Cristina, Novkovic Mario