A PHASE III, RANDOMIZED, DOUBLEBLIND, PLACEBOCONTROLLED, MULTICENTER STUDY TO EVALUATE THE EFFICACY AND SAFETY OF ETROLIZUMAB AS AN INDUCTION AND MAINTENANCE TREATMENT FOR PATIENTS WITH MODERATELY TO SEVERELY ACTIVE CROHN’S DISEASE

Clinical Studies - Aug 1, 2017 - Aug 1, 2021

Automatically Closed

Project leader: Borovicka Jan, Brand Stephan
Members: Dora Barbara, Frei Remus, Knellwolf Christina, Semadeni Gian-Marco, Sulz Michael

A Phase 3, Randomized, Double-Blinded, Placebo-Controlled, Multicenter Study of Amiselimod (MT-1303) in the Induction and Maintenance of Clinical Response and Remission in Subjects With Moderate to Severe Ulcerative Colitis

Clinical Studies - Jun 1, 2017 - Sep 27, 2022

Automatically Closed

Members: Knellwolf Christina, Dora Barbara, Krieger-Grübel Claudia, Sulz Michael

A Phase 3, randomized, double-blind, placebo-controlled, multicenter study to investigate the efficacy and safety of mongersen (GED-0301) for the treatment of subjects with active Crohn’s disease.

Clinical Studies - Dec 1, 2016 - Dec 1, 2018

Completed

Members: Dora Barbara, Knellwolf Christina, Krieger-Grübel Claudia, Sulz Michael

Randomized, double-blind, double-dummy, placebo-controlled, Phase III clinical trial on the efficacy and safety of a 48-weeks treatment with gastroresistant phosphatidylcholine (LT-02) versus placebo versus mesalamine for maintenance of remission in...

Clinical Studies - Dec 1, 2016 - Dec 1, 2018

Completed

Members: Dora Barbara, Knellwolf Christina, Krieger-Grübel Claudia, Sulz Michael

A Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Safety and Efficacy of ABT-494 for Induction and Maintenance Therapy in Subjects with Moderately to Severely Active Ulcerative Colitis

Clinical Studies - Dec 1, 2016 - Dec 1, 2018

Automatically Closed

Members: Dora Barbara, Knellwolf Christina, Krieger-Grübel Claudia, Sulz Michael

Entyvio (vedolizumab) long-term safety study: An international observational prospective cohort study comparing vedolizumab to other biologic agents in patients with ulcerative colitis or Crohn’s Disease. This is a prospective, observational, multi-...

Clinical Studies - Jul 28, 2016 - Jun 28, 2022

Automatically Closed

Project leader: Brand Stephan
Members: Dora Barbara, Knellwolf Christina, Sulz Michael, Krieger-Grübel Claudia

In dieser Studie sollen neue Methoden zur Messung von ALS-Symptomen während des Verlaufs der Erkrankung beobachtet werden, um festzustellen, ob mit diesen neuen Ansätzen Veränderungen besser erkannt werden können als mit den derzeit verwendeten Metho...

Clinical Studies - May 1, 2016 - Jun 1, 2018

Automatically Closed

Project leader: Weber Markus
Members: Neuwirth Christoph, Burkhardt Christian, Sommer Helma

The primary objectives of the study are to estimate and rank-order the longitudinal standardized mean changes over 6 months and over 12 months, for a set of outcome measures administered to participants with amyotrophic lateral sclerosis (ALS), in or...

Clinical Studies - Apr 2, 2016 - Aug 14, 2019

Completed

Project leader: Weber Markus
Members: Neuwirth Christoph

Randomized, double-blind, double-dummy, placebo-controlled, Phase III clinical trial on the efficacy and safety of a 12-weeks add-on treatment with LT-02 (gastro-resistant phosphatidylcholine granules) vs. placebo in patients with ulcerative colitis...

Clinical Studies - Mar 1, 2016 - Dec 31, 2017

Aborted

Members: Dora Barbara, Knellwolf Christina, Sulz Michael, Krieger-Grübel Claudia

GA29103: PHASE III, RANDOMIZED, MULTICENTER DOUBLE-BLIND, DOUBLE-DUMMY STUDY TO EVALUATE THE EFFICACY AND SAFETY OF ETROLIZUMAB COMPARED WITH INFLIXIMAB IN PATIENTS WITH MODERATE TO SEVERE ACTIVE ULCERATIVE COLITIS WHO ARE NAIVE TO TNF INHIBITORS

Clinical Studies - Jun 28, 2015 - Jun 28, 2020

Automatically Closed

Project leader: Borovicka Jan
Members: Dora Barbara, Frei Remus, Knellwolf Christina, Sulz Michael, Semadeni Gian-Marco

Gewinnung von kutanen Stammzellen mittels Stanzbiopsie bei Patienten mit genetischer amyotropher Lateralsklerose sowie asymptomatischen Angehörigen mit und ohne Mutationsnachweis.

Fundamental Research - Apr 1, 2015 - Dec 31, 2017

Completed

Project leader: Weber Markus

A Multicenter, Open-Label Study to Evaluate the Long Term Efficacy, Safety, and Tolerability of Repeated Administration of Adalimumab in Subjects with Crohn's Disease

Clinical Studies - Mar 1, 2015 - Dec 1, 2017

Completed

Project leader: Borovicka Jan
Members: Frei Remus, Knellwolf Christina, Semadeni Gian-Marco, Sulz Michael

A Double-Blind, Randomized, Multicenter Study of Higher Versus Standard Adalimumab Dosing Regimens for Induction and Maintenance Therapy in Subjects with Moderately to Severely Active Ulcerative Colitis This Phase 3 study design includes a Screening...

Clinical Studies - Mar 1, 2015 - Feb 1, 2018

Automatically Closed

Project leader: Borovicka Jan
Members: Dora Barbara, Frei Remus, Knellwolf Christina, Semadeni Gian-Marco, Sulz Michael

A Multicenter, Randomisierte, Double-Blind Study to Evaluate the Efficacyand Safety of Two Adalimumab Induction Regimens in Subjects with Moderately to Severely Active Crohns Disease and Evidence of Mucosal Ulceration

Clinical Studies - Feb 1, 2015 - Feb 15, 2018

Automatically Closed

Members: Frei Remus, Knellwolf Christina, Semadeni Gian-Marco, Sulz Michael, Dora Barbara

Dieser Studie wird als internationales Projekt europaweit an verschiedenen spezialisierten ALS-Zentren durchgeführt. Hintergrund ist die Tatsache, dass die genauen Ursachen oder Risikofaktoren, die zu der Erkrankung ALS führen zu einem grossen Teil u...

Clinical Studies - Jan 1, 2015 - Dec 31, 2017

Completed

Project leader: Burkhardt Christian, Weber Markus
Members: Neuwirth Christoph

PHASE III, BLINDED, PLACEBO-CONTROLLED, MULTICENTER STUDY OF THE EFFICACY AND SAFETY OF ETROLIZUMAB DURING INDUCTION AND MAINTENANCE IN PATIENTS WITH MODERATE TO SEVERE ACTIVE ULCERATIVE COLITIS WHO ARE REFRACTORY TO OR INTOLERANT OF TNF INHIBITORS

Clinical Studies - Jan 1, 2015 - Dec 31, 2017

Automatically Closed

Project leader: Borovicka Jan
Members: Dora Barbara, Frei Remus, Knellwolf Christina, Semadeni Gian-Marco, Sulz Michael

GA28951: AN OPEN-LABEL EXTENSION AND SAFETY MONITORING STUDY OF MODERATE TO SEVERE ULCERATIVE COLITIS PATIENTS PREVIOUSLY ENROLLED IN ETROLIZUMAB PHASE III STUDIES

Clinical Studies - Jun 28, 2014 - Jun 28, 2020

Completed

Project leader: Borovicka Jan
Members: Dora Barbara, Frei Remus, Knellwolf Christina, Semadeni Gian-Marco, Sulz Michael

Bei der ALS handelt es sich um eine seltene neurodegenerative Erkrankung (Prävalenz ca. 5/100.000). Muskelkrämpfe sind ein häufiges Begleitsymptom und können erheblich sein und die Betroffenen sehr belasten und folglich die Lebensqualität deutlich ei...

Clinical Studies - Nov 1, 2013 - Mar 26, 2020

Automatically Closed

Project leader: Neuwirth Christoph
Members: Burkhardt Christian, Weber Markus

Die Amyotrophe Lateralsklerose wurde lange als eine Erkrankung angesehen die ausschliesslich die Funktion der Skelettmuskulatur und deren Steuerung betrifft. Mittlerweile gilt nach den Ergebnissen von vielen unabhängigen Studien als anerkannt, dass e...

Clinical Studies - Jul 17, 2013 - Jul 15, 2015

Completed

Project leader: Burkhardt Christian
Members: Weber Markus

An Open-Label Multicenter Study to Evaluate the Impact of Adalimumab on Quality of Life, Health Care Utilization and Costs of Ulcerative Colitis Subjects in the Usual Clinical Practice Setting The primary objective is to assess the effect of adalimu...

Clinical Studies - Jun 14, 2012 - Jun 30, 2014

Completed

Project leader: Borovicka Jan
Members: Frei Remus, Knellwolf Christina