Unit
Institute of Immunobiology
IMMBIO · Management
Stroma Cell- Immune Cell Interactions in Health and Disease
Jan 1, 2012STROMA is an Initial Training Network promoting the study of stromal cell – immune system interactions during stroma development and function in health and disease. In STROMA we have bought together world leading experts from academia and industry in...
Fundamental Research - Jan 1, 2012 - Dec 31, 2015
Completed
Project leader: Ludewig Burkhard, Tarte Karin, Sixt Michael, Dzionek Andrzej, Mueller Christopher George, Hazel Jones, Giese Christoph, Cupedo Tom, de Boer Jan, Kaye Paul, Veiga Fernandes Henrique
Members: Novkovic Mario, Cheng Hung-Wei, Mörbe Urs
Genetic modification of the human airway epithelium – a paradigmatic system to study host responses to human respiratory viruses
Jan 1, 2012The goal of this project is to establish a unique experimental system to study fundamental aspects of human respiratory virus replication and interactions with the innate immune system at the natural entry port of human respiratory viruses, namely th...
Fundamental Research - Jan 1, 2012 - Dec 31, 2012
Completed
Project leader: Thiel Volker
Members: Dijkman Ronald
Polyvalent vaccine against Salmonellosis
Nov 1, 2011The major aim of this project is to generate a polyvalent vaccine candidate using microencapsulates Salmonella typhi proteins for oral administration. To this end, the laboratory in Mexico will produce sufficient amounts of S. typhi porins for encaps...
Fundamental Research - Nov 1, 2011 - Apr 30, 2013
Completed
Project leader: Ludewig Burkhard
Members: Pérez Shibayama Christian Ivan, Gil Cruz Cristina
Mechanisms of antibody-mediated protection against virus-induced inflammatory demyelination
Jul 1, 2011Background: The epidemiology of multiple sclerosis (MS) suggests that environmental factors such as infections with coronaviruses critically determine the risk for this chronic demyelinating disease. Infection of the CNS with neurotropic mouse corona...
Fundamental Research - Jul 1, 2011 - Jun 30, 2013
Completed
Project leader: Gil Cruz Cristina, Ludewig Burkhard
Members: Thiel Volker
Impact of RNA modification on coronavirus-induced innate immune responses
Oct 1, 2010Eukaryotic messenger RNAs (mRNAs) play a universal role as transcripts of the genomic information that is used for the translation into proteins of a cell. Similarly, viruses that infect eukaryotic host cells produce viral mRNAs from their genome in...
Fundamental Research - Oct 1, 2010 - Sep 30, 2013
Completed
Project leader: Thiel Volker
Members: Kindler Eveline, Dijkman Ronald
Analyse der T-Zellfunktion bei Virus induzierter Chorioretinitis
Jul 1, 2010Die Chorioretinitis ist eine häufig zu visuellen Wahrnehmungsstörungen (Sehbehinderung oder gar Erblindung) führende Erkrankung. Ursache der sich flächenhaft ausdehnenden und rasch progredienten Erkrankung der Netzhaut sind oftmals virale Infektionen...
Fundamental Research - Jul 1, 2010 - Jun 30, 2013
Completed
Project leader: Ludewig Burkhard
Members: Cupovic Jovana
SARS: Ökologie und Pathogenese einer archetypischen Zoonose - Identifizierung und Charakterisierung von konservierten coronaviralen Pathogenitätsfaktoren
Jul 1, 2010Zahlreiche Beispiele vor allem aus der Veterinärmedizin belegen, dass ein Wirtswechsel bei Coronaviren keine Seltenheit ist. Dementsprechend war das Auftreten des SARS Coronavirus in der humanen Population nicht wirklich überraschend, zeigte jedoch,...
Fundamental Research - Jul 1, 2010 - Jun 30, 2013
Automatically Closed
Project leader: Thiel Volker
Members: Gil Cruz Cristina
Role of T helper cells in cardiovascular immunopathological disease
Apr 1, 2010Chronic inflammatory reactions directed against cells within the vascular wall or the myocardium are key elements in the pathogenesis of cardiovascular diseases. Although myocarditis is a rather frequent cause of death in young adults, the lack of kn...
Fundamental Research - Apr 1, 2010 - Mar 31, 2013
Completed
Project leader: Ludewig Burkhard
Members: Nindl Veronika
Impact of immune regulation on virus-induced chronic CNS inflammation and demyelination
Aug 1, 2009Background: Multiple sclerosis (MS) is an important disease affecting young adults. Epidemiological studies indicate that this disease critically depends on environmental factors, including infectious agents. It appears that infections with a variety...
Fundamental Research - Aug 1, 2009 - Sep 30, 2009
Completed
Project leader: Ludewig Burkhard, Thiel Volker
Members: Cervantes-Barragan Luisa, Cupovic Jovana
Examining the function of lymphoid organ structure during antiviral immune responses using microscopic and mesoscopic imaging
Jun 1, 2009The adaptive immune system protects us from infectious viruses and other microbes. Cells of the adaptive immune system ‐ lymphocytes and antigen‐presenting cells (APC) ‐ are highly organized in strategic tissue locations throughout...
Fundamental Research - Jun 1, 2009 - Jul 31, 2012
Completed
Project leader: Ludewig Burkhard
Members: Scandella Elke, Onder Lucas
Reverse genetic analysis of coronavirus replication
Jan 1, 2009The reverse genetic system for the mouse hepatitis virus (MHV) in combination with a murine model for coronavirus infection allows for the use of genetically modified virus and host strains to assess the full range of virus-host interactions and to d...
Fundamental Research - Jan 1, 2009 - Dec 31, 2009
Completed
Project leader: Thiel Volker
Members: Nussbacher Monika, Züst Roland
TOLERAGE: Normalisation of immune reactivity in old age – from basic mechanisms to clinical application
Apr 1, 2008Reconstitution of normal immune function in old age is generally based on boosting the response against foreign antigens, e.g. infectious microorganisms. Our focus, however, will be to normalise immune reactivity by correcting the immune dysregulati...
Fundamental Research - Apr 1, 2008 - Sep 30, 2012
Completed
Project leader: Ludewig Burkhard, Thiel Volker
Members: Cervantes-Barragan Luisa, Eugster Karin
Entwicklung einer Coronavirus basierten Multigenvakzine zum Schutz gegen Tumorerkrankungen
Jan 1, 2008Krebszellen produzieren antigenetische Zielstrukturen, die sie für einen Angriff durch spezifische Immunzellen sensibilisieren. Die effektivste Waffe des Immunsystems gegen Tumorzellen sind zytotoxische T-Zellen. Die effiziente Aktivierung dieser Kil...
Fundamental Research - Jan 1, 2008 - Dec 31, 2009
Completed
Project leader: Ludewig Burkhard, Thiel Volker
Members: Makia Divine, Nussbacher Monika
Impact of immune regulation on virus-induced chronic CNS inflammation and demyelination
Jan 1, 2008Background: Multiple sclerosis (MS) is an important disease affecting young adults. Epidemiological studies indicate that this disease critically depends on environmental factors, including infectious agents. It appears that infections with a variety...
Fundamental Research - Jan 1, 2008 - Dec 31, 2008
Completed
Project leader: Ludewig Burkhard
Members: Cervantes-Barragan Luisa, Eugster Karin
Reverse genetic analysis of coronavirus replication
Oct 1, 2007The reverse genetic system for the mouse hepatitis virus (MHV) in combination with a murine model for coronavirus infection allows for the use of genetically modified virus and host strains to assess the full range of virus-host interactions and to d...
Fundamental Research - Oct 1, 2007 - Sep 30, 2010
Completed
Project leader: Thiel Volker
Members: Nussbacher Monika, Züst Roland
Role of professional and non-professional antigen presenting cells in cardiovascular immunopathological disease
Apr 1, 2007The importance of chronic inflammatory processes in the pathogenesis of cardiovascular diseases is now widely recognized. Atherosclerosis and autoimmune myocarditis are prototypical diseases illustrating the detrimental effects of constant immune act...
Fundamental Research - Apr 1, 2007 - Mar 31, 2010
Completed
Project leader: Ludewig Burkhard
Members: Eugster Karin, Nindl Veronika
Multiepitop Imfpung von Grad III/IV Melanompatienten mit dendritischen Zellen: Bedeutung von Peptidaffinität und -dichte für die optimale Generierung von tumorspezifischen zytotoxischen T-Lymphozyten
Jan 1, 2007Die immunologische Forschung der letzten Jahre hat deutlich gemacht, dass Krebszellen Zielstrukturen, sogenannte Antigene, produzieren, die sie für einen Angriff durch spezifische Immunzellen sensibilisieren. Die effektivste Waffe des Immunsystems ge...
Clinical Studies - Jan 1, 2007 - Dec 31, 2009
Completed
Project leader: Ludewig Burkhard, Gillessen Sommer Silke, Cerny Thomas
Members: Maier Reinhard, Templeton Arnoud
Immunpathologie der Virus induzierten Chorioretinitis
Jan 1, 2007Die Chorioretinitis ist eine häufig zu visuellen Wahrnehmungsstörungen (Sehbehinderung oder gar Erblindung) führende Erkrankung. Ursache der sich flächenhaft ausdehnenden und rasch progredienten Erkrankung der Netzhaut sind oftmals virale Infektionen...
Fundamental Research - Jan 1, 2007 - Dec 31, 2009
Completed
Project leader: Ludewig Burkhard
Preventing autoimmune myocarditis through cardiac myosin-specific tolerance
Jan 1, 2007The exact pathological basis of human myocarditis has not yet been sufficiently clarified and therefore, the appropriate treatment has remained a major clinical problem. Assuming that immunopathological damage contributes to the inflammatory nature o...
Fundamental Research - Jan 1, 2007 - Dec 31, 2009
Completed
Project leader: Ludewig Burkhard
Members: Nindl Veronika, Maier Reinhard
AIDS-CoVAC: Generation of a coronavirus-based multigene AIDS vaccine and evaluation in a preclinical SIV model
Dec 1, 2006Coronaviruses spread via mucosal surfaces and can infect dendritic cells. These features and their exceptional transcription strategy make them extremely promising candidate vaccine vectors to overcome known problems of current HIV vaccine approaches...
Fundamental Research - Dec 1, 2006 - May 31, 2009
Completed
Project leader: Ludewig Burkhard, Thiel Volker
Members: Eugster Karin, Cervantes-Barragan Luisa, Makia Divine