Projects

Fundamental Research - Jul 9, 2015 - Jul 9, 2016

Completed

Project leader: Jochum Wolfram

MO29518 ist eine offene, multizentrische, multinationale Phase-II-Studie mit 10 Kohorten, welche MPDL3280A (Anti-PD-L1 Antikörper) bei Patienten mit fortgeschrittenen soliden Tumoren untersucht (Gebärmutterhalskrebs, Nasen-Rachenkrebs, spezielle Art...

Clinical Studies - Jul 8, 2015 - Jul 31, 2019

Automatically Closed

Project leader: Gillessen Sommer Silke
Members: Schmid Sabine, Fischer Stefanie, Rothermundt Christian, Templeton Arnoud, Omlin Aurelius, Desax Marie-Claire, Früh Martin, Weisshaupt Christian

The overall aim of the present study is to investigate if positive and negative airway pressure influences cardiopulmonary- and hemodynamic responses by adding resistive loads or/and conducting NPPV throughout the entire breathing cycle in patients w...

Fundamental Research - Jul 1, 2015 - Mar 1, 2016

Automatically Closed

Project leader: van Gestel Arno Jr
Members: Baty Florent, Brutsche Martin

GA29103: PHASE III, RANDOMIZED, MULTICENTER DOUBLE-BLIND, DOUBLE-DUMMY STUDY TO EVALUATE THE EFFICACY AND SAFETY OF ETROLIZUMAB COMPARED WITH INFLIXIMAB IN PATIENTS WITH MODERATE TO SEVERE ACTIVE ULCERATIVE COLITIS WHO ARE NAIVE TO TNF INHIBITORS

Clinical Studies - Jun 28, 2015 - Jun 28, 2020

Automatically Closed

Project leader: Borovicka Jan
Members: Dora Barbara, Frei Remus, Knellwolf Christina, Sulz Michael, Semadeni Gian-Marco

The overall aim of the present study is to investigate if a PA counselling program during PR increases PA level in daily life in patients with COPD.

Fundamental Research - Jun 15, 2015 - Jan 31, 2017

Automatically Closed

Project leader: van Gestel Arno Jr
Members: Rausch Osthoff Anne-Kathrin, Baty Florent, Hess Thomas

The primary aim of the present study is to analyze the validity and feasibility of a wearable ECG Acquisition System (EMPA) by comparing standard measures of heart rate variability (Low-frequency power, LF) with those of polysomnography.

Fundamental Research - Jun 1, 2015 - Dec 1, 2016

Automatically Closed

Project leader: Brutsche Martin
Members: Baty Florent, van Gestel Arnoldus, Rossi Rene, Annaheim Simon, Weder Markus, Schoch Otto

To evaluate the effect of AMG 334 compared to placebo on the change from baseline in monthly migraine days, in subjects with episodic migraine

Clinical Studies - Jun 1, 2015 - Dec 31, 2017

Automatically Closed

Project leader: Flügel Dominique
Members: Zieglgänsberger Dominik, Müller Anna

Among all the bones in the foot the calcaneus is the most commonly fractured one, counting for 1 – 2% of all fractures. Calcaneus fractures are very complex injuries with regard to the damage of the bone, the cartilage of the subtalar joint and the s...

Clinical Studies - May 15, 2015 - Dec 31, 2016

Automatically Closed

Project leader: Schirm Andreas

STUDY DESIGN Overview of Study Design This is a non-interventional, multicenter, study consisting of 2 prospective cohorts of patients diagnosed with moderate to severe active RA and initiated/treated with abatacept SC. In some countries, patients ca...

Clinical Studies - May 6, 2015 - Oct 6, 2017

Completed

Project leader: Müller Rüdiger
Members: Forrer Silvia, Schmidig Kathrin, Bartz-Batliner Mira, Hutz Carina Liane

Dies ist eine globale, multizentrische, offene, zweiarmige, randomisierte, kontrollierte Phase-III Studie zur Beurteilung der Wirksamkeit und Sicherheit von MPDL3280A im Ver-gleich mit Chemotherapie bei Patienten mit lokal fortge-schrittenem oder met...

Clinical Studies - Apr 2, 2015 - Dec 1, 2016

Automatically Closed

Project leader: Gillessen Sommer Silke
Members: Templeton Arnoud, Rothermundt Christian, Omlin Aurelius, Desax Marie-Claire

Systemic lupus erythematosus (SLE) is a chronic multisystem autoimmune disease. So far, there is little evidence for the existence of specific biologic markers reliably indicating clinical activity and a rather wide panel of unspecific markers indica...

Fundamental Research - Apr 1, 2015 - Mar 31, 2018

Automatically Closed

Project leader: von Kempis Johannes
Members: Schmiedeberg Kristin

Gewinnung von kutanen Stammzellen mittels Stanzbiopsie bei Patienten mit genetischer amyotropher Lateralsklerose sowie asymptomatischen Angehörigen mit und ohne Mutationsnachweis.

Fundamental Research - Apr 1, 2015 - Dec 31, 2017

Completed

Project leader: Weber Markus

Traditional chemotherapy fails to cure renal cell carcinoma (RCC), hence novel approaches and mechanisms need to be exploited.Proteotoxic stress-induced apoptosis can be induced in cancer cells by interfering with the homeostasis of protein biosynthe...

Fundamental Research - Mar 31, 2015 - Dec 7, 2018

Automatically Closed

Project leader: Abt Dominik
Members: Engeler Daniel, Driessen Christoph, Kraus Marianne, Bader Jürgen

Clinical Studies - Mar 30, 2015 - Sep 30, 2017

Completed

Members: Alfter Christine, Bernsmeier Christine, Künzler-Heule Patrizia, Semela David

Der Schlaganfall ist die zweithäufigste Todesursache und die häufigste Ursache einer erworbenenBehinderung im Erwachsenenalter. Für die meisten Patienten ist eine effiziente Sekundärprophylaxe die wirksamste Prävention um die Häufigkeit von Schlaganf...

Clinical Studies - Mar 30, 2015 - Mar 31, 2016

Completed

Project leader: Kägi Georg
Members: Vehoff Jochen

Clinical Studies - Mar 26, 2015 - Mar 31, 2020

Automatically Closed

Project leader: Semela David
Members: Bernsmeier Christine, Künzler-Heule Patrizia, Stillhard Roman

Kurzzeitige duale Thrombozytenaggregationshemmer-Therapie mit Everolimus freisetzenden Stents Synergy® II bei Patienten über 75 Jahren, die eine perkutane Koronarrevaskularisierung erhalten. Ziele: Nachweis der Wirksamkeit und Sicherheit der Everol...

Clinical Studies - Mar 26, 2015 - Nov 30, 2018

Completed

Project leader: Weilenmann Daniel
Members: Schneider Irene

Register-Studie Emphysema

Clinical Studies - Mar 24, 2015 - Mar 24, 2017

Aborted

Project leader: Schneider Tino
Members: Brutsche Martin, Kapfer Sarah, Schlotter Sandra

A prospective multicenter study to assess the coreelation of LONGterm wrist ACTigraphy recorded physical Performance and 6-minute walk distance in patients with pulmonary arterial Hypertension newly initiating endothelin receptor antagonist therapy

Clinical Studies - Mar 24, 2015 - Mar 24, 2015

Aborted

Project leader: Brutsche Martin
Members: Baty Florent, Kapfer Sarah, Schlotter Sandra, Schoch Otto

A randomized phase II multicenter study with a safety run-in to assess the tolerability and efficacy of the addition of oral tosedostat to standard induction therapy in AML and high risk myelodysplasia (MDS) (IPSS-R risk score > 4.5) in patients aged...

Clinical Studies - Mar 19, 2015 - Mar 19, 2015

Automatically Closed

Project leader: Hess Urs
Members: Hitz Felicitas, Baumann Michael, Driessen Christoph, Fehr Martin, Silzle Tobias