Projects

Mit 5500 Neuerkrankungen im Jahr ist Brustkrebs mit Abstand die häufigste Krebserkrankung bei Schweizer Frauen. Fast 30% der Krebserkrankungen bei Frauen betreffen die Brust und Brustkrebs ist verantwortlich für rund 1350 Todesfälle pro Jahr. Schätz...

Clinical Studies - Mar 12, 2015 - Aug 27, 2017

Automatically Closed

Project leader: Chiesa Federica
Members: Knauer Michael

We have developed the Predictive Swallowing Score (PRESS) - an easily applicable prognostic risk score of impaired oral intake after stroke. The 10 point score is calculated after the initial swallowing evaluation in the first days after stroke and s...

Clinical Studies - Mar 1, 2015 - Dec 31, 2016

Automatically Closed

Project leader: Kägi Georg
Members: Galovic Marian, Leisi Natascha, Müller Marlise, Stöckli Sandro, Arnold Marcel, Lyrer Philippe, Kahles Timo

A Multicenter, Open-Label Study to Evaluate the Long Term Efficacy, Safety, and Tolerability of Repeated Administration of Adalimumab in Subjects with Crohn's Disease

Clinical Studies - Mar 1, 2015 - Dec 1, 2017

Completed

Project leader: Borovicka Jan
Members: Frei Remus, Knellwolf Christina, Semadeni Gian-Marco, Sulz Michael

A Double-Blind, Randomized, Multicenter Study of Higher Versus Standard Adalimumab Dosing Regimens for Induction and Maintenance Therapy in Subjects with Moderately to Severely Active Ulcerative Colitis This Phase 3 study design includes a Screening...

Clinical Studies - Mar 1, 2015 - Feb 1, 2018

Automatically Closed

Project leader: Borovicka Jan
Members: Dora Barbara, Frei Remus, Knellwolf Christina, Semadeni Gian-Marco, Sulz Michael

VAlidation of an 8-­‐item-­‐questionnaire predictive for a positive CaLprotectin tEst and Real-­‐life implemenTation in primary care to reduce diagnostic delay in inflammatory bowel disease

Clinical Studies - Feb 28, 2015 - Jan 30, 2017

Completed

Project leader: Borovicka Jan
Members: Dora Barbara, Sulz Michael

The objective is to establish telehealthcare as an integrated, web-based treatment network between patient, GP and hospital to optimise care for COPD patients according to the GOLD-guidelines, assisted by simple-to-use, network-based gadgets (via sma...

Clinical Studies - Feb 1, 2015 - Feb 1, 2016

Completed

Project leader: Brutsche Martin
Members: Baty Florent, Dusemund Frank

A Multicenter, Randomisierte, Double-Blind Study to Evaluate the Efficacyand Safety of Two Adalimumab Induction Regimens in Subjects with Moderately to Severely Active Crohns Disease and Evidence of Mucosal Ulceration

Clinical Studies - Feb 1, 2015 - Feb 15, 2018

Automatically Closed

Members: Frei Remus, Knellwolf Christina, Semadeni Gian-Marco, Sulz Michael, Dora Barbara

Entwicklung eines systematischen Validierngsprozesses für Patienteninformationsbroschüren am Beispiel einer Aufklärungsbroschüre für Harnleiterschienen

Clinical Studies - Jan 18, 2015 - Dec 18, 2016

Automatically Closed

Project leader: Abt Dominik
Members: Schmid Hans-Peter, Betschart Patrick, Sauter Rafael, Zumstein Valentin, Staubli Sergej

The aim of this registry is to prolong the patient observation period and recruit new patients to gain further insights into the long-term use of NOACs, including switching from Vitamin K antagonists (VKAs), to NOACs in a real life setting. This will...

Clinical Studies - Jan 15, 2015 - Mar 31, 2016

Completed

Project leader: Ammann Peter
Members: Gemperle Michaela

The aim of the study is to investigate the prevalence and course of sarcopenia in patients undergoing curative trimodality therapy for locally advanced esophageal cancer and to correlate skeletal muscle mass with treatment complications during neoadj...

Clinical Studies - Jan 13, 2015 - Dec 31, 2015

Automatically Closed

Project leader: Panje Cédric, Henke Guido
Members: Blum David

Healthcare Research - Jan 10, 2015 - Feb 21, 2018

Completed

Project leader: Thanner Mirjam
Members: von Perbandt Evelyn, Hornung René

Proteasom-Inhibitor (PI) Resistenz ist eines der Schlüsselprobleme in der Therapie des Multiplen Myeloms (MM), der häufigsten hämatologischen Neoplasie. Wir haben in Vorarbeiten ein in vitro-Modell des PI-resistenten MM entwickelt und Biologie-basier...

Fundamental Research - Jan 5, 2015 - Dec 31, 2015

Automatically Closed

Project leader: Driessen Christoph
Members: Besse Lenka

Hintergrund Die CMV-Infektion ist die häufigste Viruserkrankung nach Transplantation und ist nach wie vor mit einer hohen Morbidität verbunden. Die antiviralen Medikamente haben sich in der Prävention der CMV-Infektion als nützlich erwiesen, vor all...

Clinical Studies - Jan 1, 2015 - Dec 31, 2018

Completed

Project leader: Binet Françoise-Isabelle

Studie zur Evaluation einer optimalen Teststrategie auf die wichtigsten sexuell übertragbaren Erkrankungen (STD) bei symptomfreien Personen

Clinical Studies - Jan 1, 2015 - Dec 31, 2015

Automatically Closed

Project leader: Vernazza Pietro

Intestinal homeostasis requires codependent interactions between the intestinal epithelium, the microbiota and the immune system. Innate lymphoid cells (ILCs) play critical roles in intestinal homeostasis, the regulation of intestinal epithelial cell...

Fundamental Research - Jan 1, 2015 - Dec 31, 2015

Automatically Closed

Project leader: Scandella Elke

Dieser Studie wird als internationales Projekt europaweit an verschiedenen spezialisierten ALS-Zentren durchgeführt. Hintergrund ist die Tatsache, dass die genauen Ursachen oder Risikofaktoren, die zu der Erkrankung ALS führen zu einem grossen Teil u...

Clinical Studies - Jan 1, 2015 - Dec 31, 2017

Completed

Project leader: Burkhardt Christian, Weber Markus
Members: Neuwirth Christoph

Eine randomisierte, doppelblinde, kontinuierlich verabreichte, placebokontrollierte, multizentrische klinische Prüfung der Phase III zur Untersuchung der Wirksamkeit und Sicherheit von 2 Dosierungen Benralizumab (MEDI-563) bei Pat. mit moderater bis...

Clinical Studies - Jan 1, 2015 - Jan 1, 2016

Automatically Closed

Project leader: Brutsche Martin
Members: Benz Gabriel

Activating mutations in lung cancer are targeted by a series of molecularly targeted therapies. Patients harboring such mutations can receive significant benefit from these therapies. However a proportion of patients without activating mutations can...

Fundamental Research - Jan 1, 2015 - Dec 31, 2016

Automatically Closed

Project leader: Baty Florent
Members: Franzini Anca, Früh Martin, Jörger Markus, Brutsche Martin

PHASE III, BLINDED, PLACEBO-CONTROLLED, MULTICENTER STUDY OF THE EFFICACY AND SAFETY OF ETROLIZUMAB DURING INDUCTION AND MAINTENANCE IN PATIENTS WITH MODERATE TO SEVERE ACTIVE ULCERATIVE COLITIS WHO ARE REFRACTORY TO OR INTOLERANT OF TNF INHIBITORS

Clinical Studies - Jan 1, 2015 - Dec 31, 2017

Automatically Closed

Project leader: Borovicka Jan
Members: Dora Barbara, Frei Remus, Knellwolf Christina, Semadeni Gian-Marco, Sulz Michael

Study design: For the pilot trial a single stage phase II design was chosen. All patients that meet the eligibility criteria will receive carboplatin AUC3 until progression (radiological or clinical). A total of 25 patients are required for this stud...

Clinical Studies - Dec 2, 2014 - Dec 31, 2017

Automatically Closed

Project leader: Omlin Aurelius
Members: Gillessen Sommer Silke, Haile Sarah, Jochum Wolfram