Projects
Search from 1164 projects:
1164 Project(s)
Methodologische Studie neuartiger elektrophysiologischer, physikalischer und bildgebender Messgrössen zur Beurteilung der Krankheitsprogression bei amyotropher Lateralsklerose
May 1, 2016In dieser Studie sollen neue Methoden zur Messung von ALS-Symptomen während des Verlaufs der Erkrankung beobachtet werden, um festzustellen, ob mit diesen neuen Ansätzen Veränderungen besser erkannt werden können als mit den derzeit verwendeten Metho...
Clinical Studies - May 1, 2016 - Jun 1, 2018
Automatically Closed
Project leader: Weber Markus
Members: Neuwirth Christoph, Burkhardt Christian, Sommer Helma
A phase III, open-label, randomized study of MPDL3280A (AntiPD-L1 antibody) in combination with carboplatin Paclitaxel with or without bevacizumab compared with carboplatin Paclitaxel bevacizumab in chemotherapy naïve patients with stage IV non-squamous non-small cell lung cancer
Apr 14, 2016MPDL3280A ist ein humaner monoklonaler Antikörper der Immunglobulin (Ig)-Klasse G1 und wird in den Ovarialzellen des chinesischen Hamsters produziert. MPDL3280A wird als mögliche Therapie gegen solide Tumore und hämatologische Malignitäten in Mensche...
Clinical Studies - Apr 14, 2016 - Apr 14, 2020
Automatically Closed
Project leader: Früh Martin
Methodology Study of Novel Outcome Measures to Assess Progression of ALS
Apr 2, 2016The primary objectives of the study are to estimate and rank-order the longitudinal standardized mean changes over 6 months and over 12 months, for a set of outcome measures administered to participants with amyotrophic lateral sclerosis (ALS), in or...
Clinical Studies - Apr 2, 2016 - Aug 14, 2019
Completed
Project leader: Weber Markus
Members: Neuwirth Christoph
ARTESIA
Apr 1, 2016Study Hypothesis: In patients with evidence of device-detected sub-clinical atrial fibrillation (SCAF) and additional risk factors for stroke, treatment with apixaban compared with aspirin will reduce the risk of the composite of stroke and systemic...
Clinical Studies - Apr 1, 2016 - Jan 1, 2026
Completed
Project leader: Ammann Peter
Members: Gemperle Michaela, Brenner Roman, Fink Karin, Vetsch Susanne
Defining the origin of lymph node and Peyer's patch fibroblastic reticular cells at single cell resolution
Apr 1, 2016Secondary lymphoid organs such as lymph nodes (LNs) and Peyer’s patches (PPs) sample antigens from the body’s inner and outer surfaces and mediate optimal interaction of immune cells. These functions rely on the presence of specialized microenvironme...
Fundamental Research - Apr 1, 2016 - Mar 31, 2019
Automatically Closed
Project leader: Ludewig Burkhard
Members: Mörbe Urs, Pérez Shibayama Christian Ivan
A randomized, phase 3 trial with anti-PD-1 monoclonal antibody pembrolizumab (MK-3475) versus placebo for patients with early stage NSCLC after resection and completion of standard adjuvant therapy (PEARLS)
Mar 30, 2016Primary/co-primary. To prospectively investigate whether adjuvant treatment with pembrolizumab after completion of radical surgery (lobectomy/pneumonectomy) with or with-out standard adjuvant chemotherapy for stage IB (T ≥ 4 cm) -II-IIIA NSCLC patien...
Clinical Studies - Mar 30, 2016 - Mar 30, 2020
Automatically Closed
Project leader: Früh Martin
APPRISE
Mar 16, 2016A Multi-Country, Multicenter, Single-Arm, Open-Label Study to Document the Safety, Tolerability and Effect of Alirocumab on atherogenic lipoproteins in High Cardio-Vascular Risk Patients With Severe Hypercholesterolemia Not Adequately Controlled With...
Clinical Studies - Mar 16, 2016 - Jul 1, 2018
Completed
Project leader: Bilz Stefan
Members: Jenni Vera, Räss Andrea
Intercept 747-303 NASH and OCA
Mar 7, 2016A Phase 3, Double-Blind, Randomized, Long-Term, Placebo-Controlled, Multicenter Study Evaluating the Safety and Efficacy of Obeticholic Acid in Subjects with Nonalcoholic Steatohepatitis
Clinical Studies - Mar 7, 2016 - Mar 7, 2021
Automatically Closed
Project leader: Semela David
Members: Alfter Christine
Intercept 747-302 PBC und OCA
Mar 7, 2016“A Phase 3b, Double-Blind, Randomized, Placebo-Controlled, Multicenter Study Evaluating the Effect of Obeticholic Acid on Clinical Outcomes in Subjects with Primary Biliary Cirrhosis”
Clinical Studies - Mar 7, 2016 - Mar 7, 2021
Automatically Closed
Project leader: Semela David
Members: Alfter Christine
SASl 36 The health burden of Primary Biliary Cirrhosis in Switzerland
Mar 7, 2016
Clinical Studies - Mar 7, 2016 - Sep 14, 2016
Completed
Project leader: Semela David
Members: Alfter Christine
Swiss Hepatitis B Cohort Study
Mar 7, 2016Swiss Hepatitis B Cohort Study
Fundamental Research - Mar 7, 2016 - Mar 7, 2016
Automatically Closed
Project leader: Semela David
Members: Alfter Christine, Zeuge Ulf
Evaluation der diagnostischen Genauigkeit und Sicherheit des Einsatzes bereits etablierter Ultraschall- und Magnetresonanz-Techniken (Elastographie, Multiparametrische Bildgebung) zur nicht-invasiven Diagnostik von Leber-/Milzerkrankungen im Vergleich zur simultanen perkutanen Leberbiopsie
Mar 7, 2016Evaluation CAP vs. Histologie Stephan Baumeler, Irina Bergamin Zusammenarbeit mit USZ Christoph Gubler und Michael Scharl
Clinical Studies - Mar 7, 2016 - Mar 7, 2020
Automatically Closed
Project leader: Semela David
Members: Alfter Christine
TICH-2: Tranexamic acid for hyperacute primary IntraCerebral Haemorrhage
Mar 1, 2016Despite development of effective treatments for ischaemic stroke (thrombolysis, aspirin, hemicraniectomy) there is no proven effective treatment for spontaneous intracerebral haemorrhage (SICH). Trials conducted with treatments such as intesive blood...
Clinical Studies - Mar 1, 2016 - Mar 1, 2018
Completed
Project leader: Kägi Georg
Members: Vehoff Jochen, Müller Anna
Merck EORTC 1325 / MK-3475-054 - Adjuvant immunotherapy with anti-PD-1 monoclonal anti-body Pembrolizumab (MK-3475) versus placebo after complete resection of high-risk Stage III melanoma: A ran-domized, double- blind Phase 3 trial of the EORTC Mela-noma Group
Mar 1, 2016This is an international, double-blinded, placebo-controlled randomized phase III trial. Enrollment will be a multi-step process. Randomization (placebo vs. pembrolizumab) will be performed centrally and will be stratified for the following factors:...
Clinical Studies - Mar 1, 2016 - Mar 1, 2020
Automatically Closed
Project leader: Fehr Martin
PCG-2/UCA
Mar 1, 2016Randomized, double-blind, double-dummy, placebo-controlled, Phase III clinical trial on the efficacy and safety of a 12-weeks add-on treatment with LT-02 (gastro-resistant phosphatidylcholine granules) vs. placebo in patients with ulcerative colitis...
Clinical Studies - Mar 1, 2016 - Dec 31, 2017
Aborted
Members: Dora Barbara, Knellwolf Christina, Sulz Michael, Krieger-Grübel Claudia
SAKK 41/14 ACTIVE-2: PHYSICAL ACTIVITY IN PATIENTS WITH METASTATIC
Feb 23, 2016
Clinical Studies - Feb 23, 2016 - May 31, 2021
Automatically Closed
Project leader: Horber Daniel
BIOSIGNAL: Biomarker signature of stroke aetiology study
Feb 20, 2016In 25-39% der Fälle kann die Schlaganfall-Ursache trotz sorgfältiger Abklärungen nicht gefunden werden1. Diese Patienten können unter Umständen nicht einer adäquaten Sekundärprävention zugeführt werden. Dies ist insbesondere der Fall bei Patienten mi...
Clinical Studies - Feb 20, 2016 - Feb 20, 2018
Automatically Closed
Project leader: Kägi Georg
Members: Müller Anna
Single arm open label phase II pilot study of carboplatin in patients with metastatic castration-resistant prostate cancer (CRPC) and PTEN-loss and/or DNA repair defects. PRO-PLAT
Feb 17, 2016Clinical studies in unselected prostate cancer patients strongly support the hypothesis that platinums have anti-tumour activity in some patients with CRPC. For patients progressing after docetaxel based chemotherapy and a novel androgen receptor tar...
Clinical Studies - Feb 17, 2016 - Jan 1, 2019
Automatically Closed
Project leader: Omlin Aurelius
Escitalopram: Effects of serotonergic neuromodulation on behavioural recovery and motor network plasticity after cortical ischemic stroke: a longitudinal, placebo-controlled study
Feb 1, 2016This randomized, double blind, placebo-controlled longitudinal study encompassing behavioural, neurophysiological and neuroimaging endpoints is designed to test our hypothesis, based on results from our previous pilot study, that serotonergic neuromo...
Clinical Studies - Feb 1, 2016 - Feb 1, 2018
Completed
Project leader: Kägi Georg
Members: Müller Anna
A multicenter, randomized, double-blind, parallel-group,placebo-controlled variable treatment duration studyevaluating the efficacy and safety of Siponimod (BAF312)in patients with secondary progressive multiple sclerosisfollowed by extended treatment with open-label BAF312
Feb 1, 2016Extensionsstudie, Evaluation Sicherheit und Wirksamkeit von Siponimod bei sekundär progredienter MS.
Clinical Studies - Feb 1, 2016 - Feb 1, 2020
Automatically Closed