Projects
Search from 1158 projects:
1158 Project(s)
Selection and education of heart-specific Th cells by thymic and lymph node stromal cells
Apr 1, 2013Myocarditis is a frequent disease in children and young adults that can precipitate lethal dilated cardiomyopathy (DCM). Since some heart antigens, such as the cardiac myosin heavy chain alpha (myhca) are not represented in the thymus, heart-specific...
Fundamental Research - Apr 1, 2013 - Mar 31, 2016
Completed
Project leader: Ludewig Burkhard
Members: Pérez Shibayama Christian Ivan, Bösch Maximilian, Gil Cruz Cristina
GeDDiS: A prospective randomised controlled phase III trial of gemcitabine and docetaxel com-pared with doxorubicin as first line treatment in previously untreated advanced unresectable or metastatic soft tissue sarcomas
Mar 31, 2013Weichteilsarkome sind seltene Tumoren, weshalb bei der Durchführung klinischer Studien Kollaborationen eingegangen werden müssen. Die Teilnahme an einer internationalen, multizentrischen, Phase III Studie bei einer Tumorentität mit Orphan Disease Sta...
Clinical Studies - Mar 31, 2013 - Dec 23, 2013
Completed
Project leader: Rothermundt Christian
Members: Cerny Thomas
COBRA PzF Coronary Stent System in Native Coronary Arteries for Early Healing, Thrombus Inhibition, Endothelialization, and Avoiding Long-Term Dual Anti-Platelet Therapy – The PzF SHIELD Trial
Mar 22, 2013The main objective of this study is to evaluate the safety and effectiveness of the COBRA PzF Coronary Stent System in the treatment of de novo lesions in native coronary arteries. The COBRA PzF Coronary Stent System is a balloon-expandable bare met...
Clinical Studies - Mar 22, 2013 - Mar 31, 2021
Completed
Project leader: Weilenmann Daniel
Members: Schneider Irene, Schefer Mirjam
Eine Untersuchung der Pathogenese des Terson Syndroms und der Rolle der Liquorproteine Gesamt-Tau / Amyloid-ß 40 und 42 bei der aneurysmatischen Subarachnoidalblutung
Mar 15, 2013Die intra-vitreale Blutung in Assoziation mit einer aneurysmatischen Subarachnoidalblutung (aSAB) ist ein häufiger Befund und wurde zuerst vom Deutschen Ophthalmologen Moritz Litten im Jahr 1881 beschrieben. Der französische Ophthalmologe Albert Ters...
Clinical Studies - Mar 15, 2013 - Mar 31, 2015
Completed
Project leader: Stienen Martin N.
Members: Joswig Holger, Fournier Jean-Yves, Valmaggia Christophe, Sédille-Mostafaie Nazanin, Korte Wolfgang, Haile Sarah
In vitro proteotoxic synergism of nelfinavir and carfilzomib in solid cancer cell lines
Mar 1, 2013HER2-positive breast cancer accounts for approximately 25-30% of all breast cancer cases, and carries a bad prognosis compared to HER2-negative breast cancer. Despite recent advances with the development of HER2-targeted treatments, mainly trastuzuma...
Fundamental Research - Mar 1, 2013 - Dec 31, 2014
Automatically Closed
Members: Driessen Christoph
Prognostic value of serial measurements of the optic nerve sheet diameter by ultrasaound in comatous patients after successful resuscitation
Feb 13, 2013Bei Patienten nach erfolgreicher Reanimation ist die neurologische Prognose schwierig beurteilbar. Insbesondere sind während den ersten 72 h nur ungenügende prognostische Schätzungen möglich. Die Sonographie des N. opticus ist einfach durchzuführen u...
Clinical Studies - Feb 13, 2013 - Feb 13, 2013
Automatically Closed
Kommunikation über Sterben und Tod aus der soziologischen Perspektive
Feb 1, 2013Hintergrund: Die Kommunikation und Interaktion mit Menschen am Lebensende liegt im gesellschaftlichen Spannungsfeld zwischen Tabu und Wiederbelebung des Todes und stellt hohe Anforderungen an die Kompetenz der Fachpersonen. Spezialistinnen und Spezia...
Clinical Studies - Feb 1, 2013 - Dec 31, 2017
Automatically Closed
Project leader: Domeisen Benedetti Franzisca
Prevention of hepatitis C virus (HCV) and HIV-1 co-infections through induction of potent T cell responses using prime-boost viral vector vaccine regimens (PEACHI)
Feb 1, 2013The goal of the PEACHI project funded by the European Commission (FP7 framework) is to develop simple, affordable and effective vaccine strategies that can be given alone or in combination to prevent hepatitis C virus (HCV), human immunodeficiency vi...
Clinical Studies - Feb 1, 2013 - Sep 27, 2022
Automatically Closed
Project leader: Dorrell Lucy, Barnes Ellie, Hoffmann Matthias, Bergin Colm, Folgori Antonella
Members: Schmid Patrick, Vernazza Pietro
Genome-wide Gene/Exon expression analysis of late stage NSCLC treated by Erlotinib /Bevacizumab: role of tumor-stroma interactions
Feb 1, 2013Genome-wide Gene/Exon expression analysis of late stage NSCLC treated by Erlotinib /Bevacizumab: role of tumor-stroma interactions
Fundamental Research - Feb 1, 2013 - Jun 1, 2015
Completed
Project leader: Baty Florent
Members: Brutsche Martin, Oliver Dürr, Franzini Anca
“The use of QUTENZA in standard clinical practice: a phase IV, multicentre, European non-interventional study” (ASCEND)
Jan 30, 2013“The use of QUTENZA in standard clinical practice: a phase IV, multicentre, European non-interventional study” (ASCEND) EKSG 12/149/1B „The use of QUTENZA in standard clinical practice: a multicentre, European NIS“. Das Ziel dieser Studie ist es, di...
Clinical Studies - Jan 30, 2013 - Jan 30, 2013
Completed
Project leader: Hoederath Petra
Members: Ott Alexander
Cetuximab monotherapy and cetuximab plus capecitabine as first-line treatment in elderly patients with KRAS- and BRAF wild-type metastatic colorectal cancer. A multicenter phase II trial, Leit-EK Zürich
Jan 10, 2013Etwa 50% der Patienten mit kolorektalem Karzinom sind bei Erstdiagnose bereits 70 Jahre oder älter. Bislang wurden allerdings nur sehr wenige Studien gezielt für ältere Patienten durchgeführt, die häufig neben der Tumorerkrankung weitere alterstypisc...
Clinical Studies - Jan 10, 2013 - Sep 27, 2022
Aborted
Project leader: Horber Daniel
Members: Gueller Ulrich, Diem Stefan
Decisision criteria guiding chemotherapy in palliative intention: Focusgroup based formal consensus for candidate criteria
Jan 6, 2013Die Wirksamkeit von Krebstherapien für Patienten mit fortgeschrittenenen, unheilbaren Krebserkrankungen wurde in klinischen Studien untersucht, hauptsächlich bezüglich der Beeinflussung des Tumorwachstums des Überlebens, und der Verträglichkeit der T...
Clinical Studies - Jan 6, 2013 - Dec 6, 2016
Automatically Closed
Project leader: Strasser Florian
Members: Magayakalbermatten N
4-P Studie
Jan 3, 2013Eine prospektive Studie zur Prognostizierbarkeit der Therapie Qualität mit Priorität auf die schmerzfreie ATP Therapie Das Ziel dieser klinischen Studie ist es, die Effektivität und die Auftretungshäufigkeit der vom ICD-Gerät (Implantierbarer Kardio...
Clinical Studies - Jan 3, 2013 - Dec 31, 2015
Completed
Project leader: Ammann Peter
Members: Altmann David, Rohner Franziska, Gemperle Michaela, Schefer Mirjam
Romanian-Swiss-Cooperation Program: IZERZ0_142226: Integration of medical oncology and palliative care procedures in various institutional and economical settings
Jan 1, 2013Summary of the research plan Background: In the care of advanced incurable cancer patients medical oncologists play a sentinel role in not only providing tumour directed treatment, but also in identifying and treating palliative care needs. In busy o...
Clinical Studies - Jan 1, 2013 - Dec 31, 2015
Completed
Project leader: Strasser Florian
Members: Wilm Simone, Magayakalbermatten N
Systems biology approach to molecularly characterize the lung cancer microenvironment
Jan 1, 2013Lung cancer is the most frequent cause of death in cancer patients in industrialized countries. Most patients with advanced nonsmall cell lung cancer (NSCLC) do not respond to the current treatment schemes indicating that the basic mechanisms of tumo...
Fundamental Research - Jan 1, 2013 - Dec 31, 2014
Completed
Project leader: Ludewig Burkhard, Brutsche Martin
Members: Baty Florent, Novkovic Mario, Onder Lucas
Role CCR7-ligands in virus-induced chronic CNS inflammation and demyelination
Jan 1, 2013Background: Epidemiological studies indicate that onset and progression of multiple sclerosis (MS) critically depends on environmental factors, including infectious agents. Experimental infections with neurotropic viruses can precipitate MS-like path...
Fundamental Research - Jan 1, 2013 - Dec 31, 2013
Completed
Project leader: Ludewig Burkhard
Members: Gil Cruz Cristina, Cupovic Jovana
Secretome analysis of the human airway epithelium following human respiratory virus infection
Jan 1, 2013The human airway epithelium represents the entry port of many human respiratory viruses, such as respiratory syncytial virus (RSV), influenza A viruses (IAV), and human coronaviruses (HCoV). It represents the interface between the external world and...
Fundamental Research - Jan 1, 2013 - Dec 31, 2013
Completed
Project leader: Thiel Volker
Members: Dijkman Ronald, Jonsdottir Hulda
Development and preclinical characterization of third-generation proteasome inhibitors
Jan 1, 2013After validation of the proteasome as a prime target for innovative oncology drugs, the peptide borate bortezomib was approved as first in class proteasome inhibiting drug. Bortezomib provides reversible inhibition of the proteasomal beta 1 and beta...
Clinical Studies - Jan 1, 2013 - Dec 31, 2015
Automatically Closed
Project leader: Driessen Christoph
Members: Kraus Marianne
Improved adherence to CPAP by Telemetric Support in Newly diagnosed OSAS Patients
Jan 1, 2013Introduction: The acceptance of positive airway pressure therapy (CPAP) within the first month is a critical aspect of successful OSAS therapy. Telemedicine is a novel tool to supervise CPAP use at patient's home. We report 30-day results of a pilot...
Fundamental Research - Jan 1, 2013 - Mar 1, 2013
Completed
Project leader: Schoch Otto, Brutsche Martin
Members: Baty Florent, Niedermann Jolanda, Rüdiger Jochen
In vitro proteotoxic synergism of nelfinavir and carfilzomib in solid cancer cell lines
Jan 1, 2013HER2-positive breast cancer accounts for approximately 25-30% of all breast cancer cases, and carries a bad prognosis compared to HER2-negative breast cancer. Despite recent advances with the development of HER2-targeted treatments, mainly trastuzuma...
Fundamental Research - Jan 1, 2013 - Dec 31, 2014
Automatically Closed
Members: Driessen Christoph, Gibbons-Marsico Jennifer, Kraus Marianne