Polymorphisms of inflammatory and metalloproteinase genes, Helicobacter pylori infection and the risk of oesophageal adenocarcinoma

Publikation

Polymorphisms of inflammatory and metalloproteinase genes, Helicobacter pylori infection and the risk of oesophageal adenocarcinoma

Wissenschaftlicher Artikel/Review - 26.02.2008

Früh Martin, Christiani D C, Shepherd F A, Lynch T J, Nishioka N S, Wain J C, Heist R S, Su L, Zhai R, Zhou W, Liu G

Zitation

Früh M, Christiani D, Shepherd F, Lynch T, Nishioka N, Wain J, Heist R, Su L, Zhai R, Zhou W, Liu G. Polymorphisms of inflammatory and metalloproteinase genes, Helicobacter pylori infection and the risk of oesophageal adenocarcinoma. British journal of cancer 2008; 98:689-92.

Art

Wissenschaftlicher Artikel/Review (Englisch)

Zeitschrift

British journal of cancer 2008; 98

Veröffentlichungsdatum

26.02.2008

ISSN (Druck)

0007-0920

Seiten

689-92

Kurzbeschreibung/Zielsetzung

Helicobacter pylori (HP) infection appears protective against oesophageal adenocarcinoma (EA) risk. Matrix metalloproteinases (MMPs) are released in the presence of HP infection. In MMP2 wild-type individuals, HP was significantly protective of EA risk (adjusted odds ratio: 0.29; 95% confidence interval=0.1-0.7). Matrix metalloproteinases may modulate the EA-HP relationship.