Polymorphisms of inflammatory and metalloproteinase genes, Helicobacter pylori infection and the risk of oesophageal adenocarcinoma

Publication

Polymorphisms of inflammatory and metalloproteinase genes, Helicobacter pylori infection and the risk of oesophageal adenocarcinoma

Journal Paper/Review - Feb 26, 2008

Früh Martin, Christiani D C, Shepherd F A, Lynch T J, Nishioka N S, Wain J C, Heist R S, Su L, Zhai R, Zhou W, Liu G

Citation

Früh M, Christiani D, Shepherd F, Lynch T, Nishioka N, Wain J, Heist R, Su L, Zhai R, Zhou W, Liu G. Polymorphisms of inflammatory and metalloproteinase genes, Helicobacter pylori infection and the risk of oesophageal adenocarcinoma. British journal of cancer 2008; 98:689-92.

Type

Journal Paper/Review (English)

Journal

British journal of cancer 2008; 98

Publication Date

Feb 26, 2008

Issn Print

0007-0920

Pages

689-92

Brief description/objective

Helicobacter pylori (HP) infection appears protective against oesophageal adenocarcinoma (EA) risk. Matrix metalloproteinases (MMPs) are released in the presence of HP infection. In MMP2 wild-type individuals, HP was significantly protective of EA risk (adjusted odds ratio: 0.29; 95% confidence interval=0.1-0.7). Matrix metalloproteinases may modulate the EA-HP relationship.