Multiple sclerosis patients express increased levels of beta-nerve growth factor in cerebrospinal fluid

Publikation

Multiple sclerosis patients express increased levels of beta-nerve growth factor in cerebrospinal fluid

Wissenschaftlicher Artikel/Review - 23.11.1992

Laudiero L B, Aloe L, Levi-Montalcini R, Buttinelli C, Schilter D, Gillessen Sommer Silke, Otten U

Bereiche

Medizinische Onkologie und Hämatologie

Schlagwörter (Tags)

Prostatakrebs

PubMed

1480330

Zitation

Laudiero L, Aloe L, Levi-Montalcini R, Buttinelli C, Schilter D, Gillessen Sommer S, Otten U. Multiple sclerosis patients express increased levels of beta-nerve growth factor in cerebrospinal fluid. Neuroscience letters 1992; 147:9-12.

Art

Wissenschaftlicher Artikel/Review (Englisch)

Zeitschrift

Neuroscience letters 1992; 147

Veröffentlichungsdatum

23.11.1992

ISSN (Druck)

0304-3940

Seiten

9-12

Kurzbeschreibung/Zielsetzung

We describe the measurement of beta-nerve growth factor (NGF) content in cerebrospinal fluid (CSF) from multiple sclerosis (MS) patients compared with CSF from age-matched normal subjects using a specific sandwich immunoassay (ELISA). During acute attacks patients exhibit a significant increase of NGF content compared to controls. In contrast during remission the mean NGF levels in CSF markedly decrease. These results strongly indicate that increased NGF production in CSF is a characteristic feature of the MS inflammatory response.