Multiple sclerosis patients express increased levels of beta-nerve growth factor in cerebrospinal fluid

Publication

Multiple sclerosis patients express increased levels of beta-nerve growth factor in cerebrospinal fluid

Journal Paper/Review - Nov 23, 1992

Laudiero L B, Aloe L, Levi-Montalcini R, Buttinelli C, Schilter D, Gillessen Sommer Silke, Otten U

Units

Medizinische Onkologie und Hämatologie

Keywords

Prostatakrebs

PubMed

1480330

Citation

Laudiero L, Aloe L, Levi-Montalcini R, Buttinelli C, Schilter D, Gillessen Sommer S, Otten U. Multiple sclerosis patients express increased levels of beta-nerve growth factor in cerebrospinal fluid. Neuroscience letters 1992; 147:9-12.

Type

Journal Paper/Review (English)

Journal

Neuroscience letters 1992; 147

Publication Date

Nov 23, 1992

Issn Print

0304-3940

Pages

9-12

Brief description/objective

We describe the measurement of beta-nerve growth factor (NGF) content in cerebrospinal fluid (CSF) from multiple sclerosis (MS) patients compared with CSF from age-matched normal subjects using a specific sandwich immunoassay (ELISA). During acute attacks patients exhibit a significant increase of NGF content compared to controls. In contrast during remission the mean NGF levels in CSF markedly decrease. These results strongly indicate that increased NGF production in CSF is a characteristic feature of the MS inflammatory response.