Randomized controlled study demonstrating failure of LPV/r monotherapy in HIV: the role of compartment and CD4-nadir

Publikation

Randomized controlled study demonstrating failure of LPV/r monotherapy in HIV: the role of compartment and CD4-nadir

Wissenschaftlicher Artikel/Review - 24.09.2010

Gutmann Christine, Vernazza Pietro, Yerly Sabine, Cavassini Matthias, Decosterd Laurent-Arthur, Hirschel Bernard, Fux Christoph, Günthard Huldrych F, Cusini Alexia, Swiss HIV Cohort Study (SHCS)

Zitation

Gutmann C, Vernazza P, Yerly S, Cavassini M, Decosterd L, Hirschel B, Fux C, Günthard H, Cusini A, Swiss HIV Cohort Study (SHCS). Randomized controlled study demonstrating failure of LPV/r monotherapy in HIV: the role of compartment and CD4-nadir. AIDS 2010; 24:2347-54.

Art

Wissenschaftlicher Artikel/Review (Englisch)

Zeitschrift

AIDS 2010; 24

Veröffentlichungsdatum

24.09.2010

eISSN (Online)

1473-5571

Seiten

2347-54

Kurzbeschreibung/Zielsetzung

Long-term side-effects and cost of HIV treatment motivate the development of simplified maintenance. Monotherapy with ritonavir-boosted lopinavir (LPV/r-MT) is the most widely studied strategy. However, efficacy of LPV/r-MT in compartments remains to be shown.