Randomized controlled study demonstrating failure of LPV/r monotherapy in HIV: the role of compartment and CD4-nadir

Publication

Randomized controlled study demonstrating failure of LPV/r monotherapy in HIV: the role of compartment and CD4-nadir

Journal Paper/Review - Sep 24, 2010

Gutmann Christine, Vernazza Pietro, Yerly Sabine, Cavassini Matthias, Decosterd Laurent-Arthur, Hirschel Bernard, Fux Christoph, Günthard Huldrych F, Cusini Alexia, Swiss HIV Cohort Study (SHCS)

Citation

Gutmann C, Vernazza P, Yerly S, Cavassini M, Decosterd L, Hirschel B, Fux C, Günthard H, Cusini A, Swiss HIV Cohort Study (SHCS). Randomized controlled study demonstrating failure of LPV/r monotherapy in HIV: the role of compartment and CD4-nadir. AIDS 2010; 24:2347-54.

Type

Journal Paper/Review (English)

Journal

AIDS 2010; 24

Publication Date

Sep 24, 2010

Issn Electronic

1473-5571

Pages

2347-54

Brief description/objective

Long-term side-effects and cost of HIV treatment motivate the development of simplified maintenance. Monotherapy with ritonavir-boosted lopinavir (LPV/r-MT) is the most widely studied strategy. However, efficacy of LPV/r-MT in compartments remains to be shown.