Doublecortin and Glypican-2 concentrations in the cerebrospinal fluid from infants are developmentally downregulated.

Publikation

Doublecortin and Glypican-2 concentrations in the cerebrospinal fluid from infants are developmentally downregulated.

Wissenschaftlicher Artikel/Review - 17.02.2023

Brégère Catherine, Fisch Urs, Halbeisen Florian Samuel, Schneider Christian, Dittmar Tanja, Stricker Sarah, Aghlmandi Soheila, Guzman Raphael

Zitation

Brégère C, Fisch U, Halbeisen F, Schneider C, Dittmar T, Stricker S, Aghlmandi S, Guzman R. Doublecortin and Glypican-2 concentrations in the cerebrospinal fluid from infants are developmentally downregulated. PloS one 2023; 18:e0279343.

Art

Wissenschaftlicher Artikel/Review (Englisch)

Zeitschrift

PloS one 2023; 18

Veröffentlichungsdatum

17.02.2023

eISSN (Online)

1932-6203

Seiten

e0279343

Kurzbeschreibung/Zielsetzung

Doublecortin (DCX) and glypican-2 (GPC2) are neurodevelopmental proteins involved in the differentiation of neural stem/progenitor cells (NSPCs) to neurons, and are developmentally downregulated in neurons after birth. In this study, we investigated whether the concentrations of DCX and GPC2 in the cerebrospinal fluid (CSF) from human pediatric patients reflect this developmental process or are associated with cerebral damage or inflammatory markers.