Doublecortin and Glypican-2 concentrations in the cerebrospinal fluid from infants are developmentally downregulated.

Publication

Doublecortin and Glypican-2 concentrations in the cerebrospinal fluid from infants are developmentally downregulated.

Journal Paper/Review - Feb 17, 2023

Brégère Catherine, Fisch Urs, Halbeisen Florian Samuel, Schneider Christian, Dittmar Tanja, Stricker Sarah, Aghlmandi Soheila, Guzman Raphael

Citation

Brégère C, Fisch U, Halbeisen F, Schneider C, Dittmar T, Stricker S, Aghlmandi S, Guzman R. Doublecortin and Glypican-2 concentrations in the cerebrospinal fluid from infants are developmentally downregulated. PloS one 2023; 18:e0279343.

Type

Journal Paper/Review (English)

Journal

PloS one 2023; 18

Publication Date

Feb 17, 2023

Issn Electronic

1932-6203

Pages

e0279343

Brief description/objective

Doublecortin (DCX) and glypican-2 (GPC2) are neurodevelopmental proteins involved in the differentiation of neural stem/progenitor cells (NSPCs) to neurons, and are developmentally downregulated in neurons after birth. In this study, we investigated whether the concentrations of DCX and GPC2 in the cerebrospinal fluid (CSF) from human pediatric patients reflect this developmental process or are associated with cerebral damage or inflammatory markers.