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Systemic and CSF Interleukin-1α Expression in a Rabbit Closed Cranium Subarachnoid Hemorrhage Model: An Exploratory Study.
Wissenschaftlicher Artikel/Review - 24.09.2019
Croci Davide Marco, Wanderer Stefan, Strange Fabio, Grüter Basil, Casoni Daniela, Sivanrupan Sivani, Widmer Hans Rudolf, Di Santo Stefano, Fandino Javier, Mariani Luigi, Marbacher Serge
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The inflammatory pathway in cerebrospinal fluid (CSF) leads to delayed cerebral vasospasm (DCVS) and delayed cerebral ischemia (DCI) after subarachnoid hemorrhage (SAH). The role of IL-1α has never been evaluated in a rabbit SAH model. The aim of our study is to analyze systemic and CSF changes of IL-1α, and to evaluate potential associations with the onset of DCVS in a rabbit closed cranium SAH model. Methods 17 New Zealand white rabbits were randomized into two groups, SAH ( = 12) and sham ( = 5). In the first group, SAH was induced by extracranial-intracranial shunting from the subclavian artery into the cerebral cistern of magna under intracranial pressure (ICP) monitoring. The sham group served as a control. The CSF and blood samples for IL-1α measurement were taken at day zero before SAH induction and at day three.