Publikation

Systemic and CSF Interleukin-1α Expression in a Rabbit Closed Cranium Subarachnoid Hemorrhage Model: An Exploratory Study.

Wissenschaftlicher Artikel/Review - 24.09.2019

Bereiche
PubMed
DOI
Kontakt

Zitation
Croci D, Wanderer S, Strange F, Grüter B, Casoni D, Sivanrupan S, Widmer H, Di Santo S, Fandino J, Mariani L, Marbacher S. Systemic and CSF Interleukin-1α Expression in a Rabbit Closed Cranium Subarachnoid Hemorrhage Model: An Exploratory Study. Brain Sci 2019; 9
Art
Wissenschaftlicher Artikel/Review (Englisch)
Zeitschrift
Brain Sci 2019; 9
Veröffentlichungsdatum
24.09.2019
ISSN (Druck)
2076-3425
Kurzbeschreibung/Zielsetzung

The inflammatory pathway in cerebrospinal fluid (CSF) leads to delayed cerebral vasospasm (DCVS) and delayed cerebral ischemia (DCI) after subarachnoid hemorrhage (SAH). The role of IL-1α has never been evaluated in a rabbit SAH model. The aim of our study is to analyze systemic and CSF changes of IL-1α, and to evaluate potential associations with the onset of DCVS in a rabbit closed cranium SAH model. Methods 17 New Zealand white rabbits were randomized into two groups, SAH ( = 12) and sham ( = 5). In the first group, SAH was induced by extracranial-intracranial shunting from the subclavian artery into the cerebral cistern of magna under intracranial pressure (ICP) monitoring. The sham group served as a control. The CSF and blood samples for IL-1α measurement were taken at day zero before SAH induction and at day three.