Systemic and CSF Interleukin-1α Expression in a Rabbit Closed Cranium Subarachnoid Hemorrhage Model: An Exploratory Study.

Publication

Systemic and CSF Interleukin-1α Expression in a Rabbit Closed Cranium Subarachnoid Hemorrhage Model: An Exploratory Study.

Journal Paper/Review - Sep 24, 2019

Croci Davide Marco, Wanderer Stefan, Strange Fabio, Grüter Basil, Casoni Daniela, Sivanrupan Sivani, Widmer Hans Rudolf, Di Santo Stefano, Fandino Javier, Mariani Luigi, Marbacher Serge

Citation

Croci D, Wanderer S, Strange F, Grüter B, Casoni D, Sivanrupan S, Widmer H, Di Santo S, Fandino J, Mariani L, Marbacher S. Systemic and CSF Interleukin-1α Expression in a Rabbit Closed Cranium Subarachnoid Hemorrhage Model: An Exploratory Study. Brain Sci 2019; 9

Type

Journal Paper/Review (English)

Journal

Brain Sci 2019; 9

Publication Date

Sep 24, 2019

Issn Print

2076-3425

Brief description/objective

The inflammatory pathway in cerebrospinal fluid (CSF) leads to delayed cerebral vasospasm (DCVS) and delayed cerebral ischemia (DCI) after subarachnoid hemorrhage (SAH). The role of IL-1α has never been evaluated in a rabbit SAH model. The aim of our study is to analyze systemic and CSF changes of IL-1α, and to evaluate potential associations with the onset of DCVS in a rabbit closed cranium SAH model. Methods 17 New Zealand white rabbits were randomized into two groups, SAH ( = 12) and sham ( = 5). In the first group, SAH was induced by extracranial-intracranial shunting from the subclavian artery into the cerebral cistern of magna under intracranial pressure (ICP) monitoring. The sham group served as a control. The CSF and blood samples for IL-1α measurement were taken at day zero before SAH induction and at day three.