Fibroblasts tune myocardial inflammation and remodeling

Publikation

Fibroblasts tune myocardial inflammation and remodeling

Wissenschaftlicher Artikel/Review - 12.08.2022

Pérez Shibayama Christian Ivan, Gil Cruz Cristina, Ludewig Burkhard

Zitation

Pérez Shibayama C, Gil Cruz C, Ludewig B. Fibroblasts tune myocardial inflammation and remodeling. Nature Cardiovascular Research 2022; 1:694–695.

Art

Wissenschaftlicher Artikel/Review (Englisch)

Zeitschrift

Nature Cardiovascular Research 2022; 1

Veröffentlichungsdatum

12.08.2022

Seiten

694–695

Kurzbeschreibung/Zielsetzung

The replacement of damaged cardiomyocytes by extracellular matrix-producing fibroblasts underpins adverse remodeling in the failing heart. New research finds that MHC class II-dependent fibroblast–CD4+ T cell interactions in the myocardium lead to fibroblast activation and exacerbate fibrotic remodeling of the myocardium.