Fibroblasts tune myocardial inflammation and remodeling

Publication

Fibroblasts tune myocardial inflammation and remodeling

Journal Paper/Review - Aug 12, 2022

Pérez Shibayama Christian Ivan, Gil Cruz Cristina, Ludewig Burkhard

Citation

Pérez Shibayama C, Gil Cruz C, Ludewig B. Fibroblasts tune myocardial inflammation and remodeling. Nature Cardiovascular Research 2022; 1:694–695.

Type

Journal Paper/Review (English)

Journal

Nature Cardiovascular Research 2022; 1

Publication Date

Aug 12, 2022

Pages

694–695

Brief description/objective

The replacement of damaged cardiomyocytes by extracellular matrix-producing fibroblasts underpins adverse remodeling in the failing heart. New research finds that MHC class II-dependent fibroblast–CD4+ T cell interactions in the myocardium lead to fibroblast activation and exacerbate fibrotic remodeling of the myocardium.