Publikation

Reset of Inflammatory Priming of Joint Tissue and Reduction of the Severity of Arthritis Flares by Bromodomain Inhibition.

Wissenschaftlicher Artikel/Review - 02.02.2023

Bereiche
PubMed
DOI
Kontakt

Zitation
Friščić J, Reinwald C, Böttcher M, Houtman M, Euler M, Chen X, Walker K, Kirchner P, Zhu H, Wirth B, Weidner D, Krüger R, Trajkovic V, Ekici A, Klein K, Mougiakakos D, Ospelt C, Schett G, Hoffmann M. Reset of Inflammatory Priming of Joint Tissue and Reduction of the Severity of Arthritis Flares by Bromodomain Inhibition. Arthritis Rheumatol 2023; 75:517-532.
Art
Wissenschaftlicher Artikel/Review (Englisch)
Zeitschrift
Arthritis Rheumatol 2023; 75
Veröffentlichungsdatum
02.02.2023
eISSN (Online)
2326-5205
Seiten
517-532
Kurzbeschreibung/Zielsetzung

We have recently shown that priming of synovial fibroblasts (SFs) drives arthritis flares. Pathogenic priming of SFs is essentially mediated by epigenetic reprogramming. Bromodomain and extraterminal motif (BET) proteins translate epigenetic changes into transcription. Here, we used a BET inhibitor (I-BET151) to target inflammatory tissue priming and to reduce flare severity in a murine experimental arthritis model.