Publication

Reset of Inflammatory Priming of Joint Tissue and Reduction of the Severity of Arthritis Flares by Bromodomain Inhibition.

Journal Paper/Review - Feb 2, 2023

Units
PubMed
Doi
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Citation
Friščić J, Reinwald C, Böttcher M, Houtman M, Euler M, Chen X, Walker K, Kirchner P, Zhu H, Wirth B, Weidner D, Krüger R, Trajkovic V, Ekici A, Klein K, Mougiakakos D, Ospelt C, Schett G, Hoffmann M. Reset of Inflammatory Priming of Joint Tissue and Reduction of the Severity of Arthritis Flares by Bromodomain Inhibition. Arthritis Rheumatol 2023; 75:517-532.
Type
Journal Paper/Review (English)
Journal
Arthritis Rheumatol 2023; 75
Publication Date
Feb 2, 2023
Issn Electronic
2326-5205
Pages
517-532
Brief description/objective

We have recently shown that priming of synovial fibroblasts (SFs) drives arthritis flares. Pathogenic priming of SFs is essentially mediated by epigenetic reprogramming. Bromodomain and extraterminal motif (BET) proteins translate epigenetic changes into transcription. Here, we used a BET inhibitor (I-BET151) to target inflammatory tissue priming and to reduce flare severity in a murine experimental arthritis model.