Publication
Reset of Inflammatory Priming of Joint Tissue and Reduction of the Severity of Arthritis Flares by Bromodomain Inhibition.
Journal Paper/Review - Feb 2, 2023
Friščić Jasna, Reinwald Christiane, Böttcher Martin, Houtman Miranda, Euler Maximilien, Chen Xiang, Walker Kellie I, Kirchner Philipp, Zhu Honglin, Wirth Benjamin, Weidner Daniela, Krüger René, Trajkovic Vladimir, Ekici Arif B, Klein Kerstin, Mougiakakos Dimitrios, Ospelt Caroline, Schett Georg, Hoffmann Markus H
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Brief description/objective
We have recently shown that priming of synovial fibroblasts (SFs) drives arthritis flares. Pathogenic priming of SFs is essentially mediated by epigenetic reprogramming. Bromodomain and extraterminal motif (BET) proteins translate epigenetic changes into transcription. Here, we used a BET inhibitor (I-BET151) to target inflammatory tissue priming and to reduce flare severity in a murine experimental arthritis model.