Reset of Inflammatory Priming of Joint Tissue and Reduction of the Severity of Arthritis Flares by Bromodomain Inhibition.

Publication

Reset of Inflammatory Priming of Joint Tissue and Reduction of the Severity of Arthritis Flares by Bromodomain Inhibition.

Journal Paper/Review - Feb 2, 2023

Friščić Jasna, Reinwald Christiane, Böttcher Martin, Houtman Miranda, Euler Maximilien, Chen Xiang, Walker Kellie I, Kirchner Philipp, Zhu Honglin, Wirth Benjamin, Weidner Daniela, Krüger René, Trajkovic Vladimir, Ekici Arif B, Klein Kerstin, Mougiakakos Dimitrios, Ospelt Caroline, Schett Georg, Hoffmann Markus H

Citation

Friščić J, Reinwald C, Böttcher M, Houtman M, Euler M, Chen X, Walker K, Kirchner P, Zhu H, Wirth B, Weidner D, Krüger R, Trajkovic V, Ekici A, Klein K, Mougiakakos D, Ospelt C, Schett G, Hoffmann M. Reset of Inflammatory Priming of Joint Tissue and Reduction of the Severity of Arthritis Flares by Bromodomain Inhibition. Arthritis Rheumatol 2023; 75:517-532.

Type

Journal Paper/Review (English)

Journal

Arthritis Rheumatol 2023; 75

Publication Date

Feb 2, 2023

Issn Electronic

2326-5205

Pages

517-532

Brief description/objective

We have recently shown that priming of synovial fibroblasts (SFs) drives arthritis flares. Pathogenic priming of SFs is essentially mediated by epigenetic reprogramming. Bromodomain and extraterminal motif (BET) proteins translate epigenetic changes into transcription. Here, we used a BET inhibitor (I-BET151) to target inflammatory tissue priming and to reduce flare severity in a murine experimental arthritis model.