Degree of crypt atypia correlates with progression to high-grade dysplasia/adenocarcinoma in non-dysplastic Barrett's oesophagus.

Publikation

Degree of crypt atypia correlates with progression to high-grade dysplasia/adenocarcinoma in non-dysplastic Barrett's oesophagus.

Wissenschaftlicher Artikel/Review - 18.05.2023

Odze Robert, Frei Nicola Fabian, Khoshiwal Amir M, Duits L C, Bergman Jacques, Stachler Matthew D

Zitation

Odze R, Frei N, Khoshiwal A, Duits L, Bergman J, Stachler M. Degree of crypt atypia correlates with progression to high-grade dysplasia/adenocarcinoma in non-dysplastic Barrett's oesophagus. Histopathology 2023; 83:406-413.

Art

Wissenschaftlicher Artikel/Review (Englisch)

Zeitschrift

Histopathology 2023; 83

Veröffentlichungsdatum

18.05.2023

eISSN (Online)

1365-2559

Seiten

406-413

Kurzbeschreibung/Zielsetzung

Patients with non-dysplastic Barrett's oesophagus (BE) often show a wide range of 'atypical' histological features in the bases of the crypts. However, the significance of crypt atypia has never been evaluated, despite prior studies showing the presence of DNA content and other molecular abnormalities in this epithelium. The aim of this study was to evaluate whether the degree of crypt atypia in BE patients without dysplasia correlates with progression to high-grade dysplasia/adenocarcinoma (HGD/EAC).