Degree of crypt atypia correlates with progression to high-grade dysplasia/adenocarcinoma in non-dysplastic Barrett's oesophagus.

Publication

Degree of crypt atypia correlates with progression to high-grade dysplasia/adenocarcinoma in non-dysplastic Barrett's oesophagus.

Journal Paper/Review - May 18, 2023

Odze Robert, Frei Nicola Fabian, Khoshiwal Amir M, Duits L C, Bergman Jacques, Stachler Matthew D

Citation

Odze R, Frei N, Khoshiwal A, Duits L, Bergman J, Stachler M. Degree of crypt atypia correlates with progression to high-grade dysplasia/adenocarcinoma in non-dysplastic Barrett's oesophagus. Histopathology 2023; 83:406-413.

Type

Journal Paper/Review (English)

Journal

Histopathology 2023; 83

Publication Date

May 18, 2023

Issn Electronic

1365-2559

Pages

406-413

Brief description/objective

Patients with non-dysplastic Barrett's oesophagus (BE) often show a wide range of 'atypical' histological features in the bases of the crypts. However, the significance of crypt atypia has never been evaluated, despite prior studies showing the presence of DNA content and other molecular abnormalities in this epithelium. The aim of this study was to evaluate whether the degree of crypt atypia in BE patients without dysplasia correlates with progression to high-grade dysplasia/adenocarcinoma (HGD/EAC).