Conditional transgenic expression of fibroblast growth factor 9 in the adult mouse heart reduces heart failure mortality after myocardial infarction.

Publikation

Conditional transgenic expression of fibroblast growth factor 9 in the adult mouse heart reduces heart failure mortality after myocardial infarction.

Wissenschaftlicher Artikel/Review - 24.01.2011

Korf-Klingebiel Mortimer, Kempf Tibor, Schlüter Klaus-Dieter, Willenbockel Christian, Brod Torben, Heineke Jörg, Schmidt Volker, Jantzen Franziska, Brandes Ralf P, Sugden Peter H, Drexler Helmut, Molkentin Jeffery D, Wollert Kai C

Zitation

Korf-Klingebiel M, Kempf T, Schlüter K, Willenbockel C, Brod T, Heineke J, Schmidt V, Jantzen F, Brandes R, Sugden P, Drexler H, Molkentin J, Wollert K. Conditional transgenic expression of fibroblast growth factor 9 in the adult mouse heart reduces heart failure mortality after myocardial infarction. Circulation 2011; 123:504-14.

Art

Wissenschaftlicher Artikel/Review (Englisch)

Zeitschrift

Circulation 2011; 123

Veröffentlichungsdatum

24.01.2011

eISSN (Online)

1524-4539

Seiten

504-14

Kurzbeschreibung/Zielsetzung

Fibroblast growth factor 9 (FGF9) is secreted from bone marrow cells, which have been shown to improve systolic function after myocardial infarction (MI) in a clinical trial. FGF9 promotes cardiac vascularization during embryonic development but is only weakly expressed in the adult heart.