Publication
Conditional transgenic expression of fibroblast growth factor 9 in the adult mouse heart reduces heart failure mortality after myocardial infarction.
Journal Paper/Review - Jan 24, 2011
Korf-Klingebiel Mortimer, Kempf Tibor, Schlüter Klaus-Dieter, Willenbockel Christian, Brod Torben, Heineke Jörg, Schmidt Volker, Jantzen Franziska, Brandes Ralf P, Sugden Peter H, Drexler Helmut, Molkentin Jeffery D, Wollert Kai C
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Journal
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Issn Electronic
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Brief description/objective
Fibroblast growth factor 9 (FGF9) is secreted from bone marrow cells, which have been shown to improve systolic function after myocardial infarction (MI) in a clinical trial. FGF9 promotes cardiac vascularization during embryonic development but is only weakly expressed in the adult heart.