Conditional transgenic expression of fibroblast growth factor 9 in the adult mouse heart reduces heart failure mortality after myocardial infarction.

Publication

Conditional transgenic expression of fibroblast growth factor 9 in the adult mouse heart reduces heart failure mortality after myocardial infarction.

Journal Paper/Review - Jan 24, 2011

Korf-Klingebiel Mortimer, Kempf Tibor, Schlüter Klaus-Dieter, Willenbockel Christian, Brod Torben, Heineke Jörg, Schmidt Volker, Jantzen Franziska, Brandes Ralf P, Sugden Peter H, Drexler Helmut, Molkentin Jeffery D, Wollert Kai C

Citation

Korf-Klingebiel M, Kempf T, Schlüter K, Willenbockel C, Brod T, Heineke J, Schmidt V, Jantzen F, Brandes R, Sugden P, Drexler H, Molkentin J, Wollert K. Conditional transgenic expression of fibroblast growth factor 9 in the adult mouse heart reduces heart failure mortality after myocardial infarction. Circulation 2011; 123:504-14.

Type

Journal Paper/Review (English)

Journal

Circulation 2011; 123

Publication Date

Jan 24, 2011

Issn Electronic

1524-4539

Pages

504-14

Brief description/objective

Fibroblast growth factor 9 (FGF9) is secreted from bone marrow cells, which have been shown to improve systolic function after myocardial infarction (MI) in a clinical trial. FGF9 promotes cardiac vascularization during embryonic development but is only weakly expressed in the adult heart.