CD4:CD8 Ratio and CD8 Cell Count and Their Prognostic Relevance for Coronary Heart Disease Events and Stroke in Antiretroviral Treated Individuals: The Swiss HIV Cohort Study.

Publikation

CD4:CD8 Ratio and CD8 Cell Count and Their Prognostic Relevance for Coronary Heart Disease Events and Stroke in Antiretroviral Treated Individuals: The Swiss HIV Cohort Study.

Wissenschaftlicher Artikel/Review - 23.09.2022

Chammartin Frédérique, Darling Katharine, Abela Irene A, Battegay Manuel, Furrer Hansjakob, Calmy Alexandra, Bernasconi Enos, Schmid Patrick, Hoffmann Matthias, Bucher Heiner C, and the Swiss HIV Cohort Study

Zitation

Chammartin F, Darling K, Abela I, Battegay M, Furrer H, Calmy A, Bernasconi E, Schmid P, Hoffmann M, Bucher H, and the Swiss HIV Cohort Study. CD4:CD8 Ratio and CD8 Cell Count and Their Prognostic Relevance for Coronary Heart Disease Events and Stroke in Antiretroviral Treated Individuals: The Swiss HIV Cohort Study. J Acquir Immune Defic Syndr 2022; 91:508.

Art

Wissenschaftlicher Artikel/Review (Englisch)

Zeitschrift

J Acquir Immune Defic Syndr 2022; 91

Veröffentlichungsdatum

23.09.2022

eISSN (Online)

1944-7884

Seiten

508

Kurzbeschreibung/Zielsetzung

HIV infection leads to a persistent expansion of terminally CD8 T cells and CD8 T suppressor cells, a marker of chronic immune activation leading to a low CD4:CD8 ratio that may persist in the presence of potent antiretroviral therapy and regained CD4 helper cells. It remains unclear whether a low CD4:CD8 ratio is associated with cardiovascular diseases.