CD4:CD8 Ratio and CD8 Cell Count and Their Prognostic Relevance for Coronary Heart Disease Events and Stroke in Antiretroviral Treated Individuals: The Swiss HIV Cohort Study.

Publication

CD4:CD8 Ratio and CD8 Cell Count and Their Prognostic Relevance for Coronary Heart Disease Events and Stroke in Antiretroviral Treated Individuals: The Swiss HIV Cohort Study.

Journal Paper/Review - Sep 23, 2022

Chammartin Frédérique, Darling Katharine, Abela Irene A, Battegay Manuel, Furrer Hansjakob, Calmy Alexandra, Bernasconi Enos, Schmid Patrick, Hoffmann Matthias, Bucher Heiner C, and the Swiss HIV Cohort Study

Citation

Chammartin F, Darling K, Abela I, Battegay M, Furrer H, Calmy A, Bernasconi E, Schmid P, Hoffmann M, Bucher H, and the Swiss HIV Cohort Study. CD4:CD8 Ratio and CD8 Cell Count and Their Prognostic Relevance for Coronary Heart Disease Events and Stroke in Antiretroviral Treated Individuals: The Swiss HIV Cohort Study. J Acquir Immune Defic Syndr 2022; 91:508.

Type

Journal Paper/Review (English)

Journal

J Acquir Immune Defic Syndr 2022; 91

Publication Date

Sep 23, 2022

Issn Electronic

1944-7884

Pages

508

Brief description/objective

HIV infection leads to a persistent expansion of terminally CD8 T cells and CD8 T suppressor cells, a marker of chronic immune activation leading to a low CD4:CD8 ratio that may persist in the presence of potent antiretroviral therapy and regained CD4 helper cells. It remains unclear whether a low CD4:CD8 ratio is associated with cardiovascular diseases.