Haptoglobin genotype and outcome after aneurysmal subarachnoid haemorrhage.

Publikation

Haptoglobin genotype and outcome after aneurysmal subarachnoid haemorrhage.

Wissenschaftlicher Artikel/Review - 14.01.2020

Morton Matthew J, Galea Ian, Werring David J, Bulters Diederik, Gaunt Tom R, Houlden Henry, Zolnourian Ardalan, Walsh Daniel, Kitchen Neil, Grieve Joan, Garland Patrick, Gaastra Benjamin, Durnford Andrew, Brown Martin M, Bonner Stephen, Alg Varinder S, Kazmi Nabila, Hostettler Isabel, ĀăąĆĉČĎ Ā ā Ă ă Ą ą Ć ć Ĉ ĉ Ċ ċ Č č Ď ď Đ đ Ē ē Ĕ ĕ Ė ė Ę ę Ě ě Ĝ ĝ Ğ ğ Ġ ġ Ģ ģ Ĥ ĥ Ħ ħ Ĩ ĩ Ī ī Ĭ ĭ Į į İ ı Ĳ ĳ Ĵ ĵ Ķ ķ ĸ Ĺ ĺ Ļ ļ Ľ ľ Ŀ ŀ Ł ł Ń ń Ņ ņ Ň ň ŉ Ŋ ŋ Ō ō Ŏ ŏ Ő ő Œ œ Ŕ ŕ Ŗ ŗ Ř ř Ś ś Ŝ ŝ Ş ş Š š Ţ ţ Ť ť Ŧ ŧ Ũ ũ Ū ū Ŭ ŭ Ů ů Ű ű Ų ų Ŵ ŵ Ŷ ŷ Ÿ Ź ź Ż ż Ž ž ſ

Zitation

Morton M, Galea I, Werring D, Bulters D, Gaunt T, Houlden H, Zolnourian A, Walsh D, Kitchen N, Grieve J, Garland P, Gaastra B, Durnford A, Brown M, Bonner S, Alg V, Kazmi N, Hostettler I, ĀăąĆĉČĎ Ā. Haptoglobin genotype and outcome after aneurysmal subarachnoid haemorrhage. J Neurol Neurosurg Psychiatry 2020; 91:305-313.

Art

Wissenschaftlicher Artikel/Review (Englisch)

Zeitschrift

J Neurol Neurosurg Psychiatry 2020; 91

Veröffentlichungsdatum

14.01.2020

eISSN (Online)

1468-330X

Seiten

305-313

Kurzbeschreibung/Zielsetzung

After aneurysmal subarachnoid haemorrhage (aSAH), extracellular haemoglobin (Hb) in the subarachnoid space is bound by haptoglobin, neutralising Hb toxicity and helping its clearance. Two exons in the gene (encoding haptoglobin) exhibit copy number variation (CNV), giving rise to HP1 and HP2 alleles, which influence haptoglobin expression level and possibly haptoglobin function. We hypothesised that the CNV associates with long-term outcome beyond the first year after aSAH.