Publication

Haptoglobin genotype and outcome after aneurysmal subarachnoid haemorrhage.

Journal Paper/Review - Jan 14, 2020

Units
PubMed
Doi
Contact

Citation
Morton M, Galea I, Werring D, Bulters D, Gaunt T, Houlden H, Zolnourian A, Walsh D, Kitchen N, Grieve J, Garland P, Gaastra B, Durnford A, Brown M, Bonner S, Alg V, Kazmi N, Hostettler I, ĀăąĆĉČĎ Ā. Haptoglobin genotype and outcome after aneurysmal subarachnoid haemorrhage. J Neurol Neurosurg Psychiatry 2020; 91:305-313.
Type
Journal Paper/Review (English)
Journal
J Neurol Neurosurg Psychiatry 2020; 91
Publication Date
Jan 14, 2020
Issn Electronic
1468-330X
Pages
305-313
Brief description/objective

After aneurysmal subarachnoid haemorrhage (aSAH), extracellular haemoglobin (Hb) in the subarachnoid space is bound by haptoglobin, neutralising Hb toxicity and helping its clearance. Two exons in the gene (encoding haptoglobin) exhibit copy number variation (CNV), giving rise to HP1 and HP2 alleles, which influence haptoglobin expression level and possibly haptoglobin function. We hypothesised that the CNV associates with long-term outcome beyond the first year after aSAH.