Haptoglobin genotype and outcome after aneurysmal subarachnoid haemorrhage.

Publication

Haptoglobin genotype and outcome after aneurysmal subarachnoid haemorrhage.

Journal Paper/Review - Jan 14, 2020

Morton Matthew J, Galea Ian, Werring David J, Bulters Diederik, Gaunt Tom R, Houlden Henry, Zolnourian Ardalan, Walsh Daniel, Kitchen Neil, Grieve Joan, Garland Patrick, Gaastra Benjamin, Durnford Andrew, Brown Martin M, Bonner Stephen, Alg Varinder S, Kazmi Nabila, Hostettler Isabel

Citation

Morton M, Galea I, Werring D, Bulters D, Gaunt T, Houlden H, Zolnourian A, Walsh D, Kitchen N, Grieve J, Garland P, Gaastra B, Durnford A, Brown M, Bonner S, Alg V, Kazmi N, Hostettler I. Haptoglobin genotype and outcome after aneurysmal subarachnoid haemorrhage. J Neurol Neurosurg Psychiatry 2020; 91:305-313.

Type

Journal Paper/Review (English)

Journal

J Neurol Neurosurg Psychiatry 2020; 91

Publication Date

Jan 14, 2020

Issn Electronic

1468-330X

Pages

305-313

Brief description/objective

After aneurysmal subarachnoid haemorrhage (aSAH), extracellular haemoglobin (Hb) in the subarachnoid space is bound by haptoglobin, neutralising Hb toxicity and helping its clearance. Two exons in the gene (encoding haptoglobin) exhibit copy number variation (CNV), giving rise to HP1 and HP2 alleles, which influence haptoglobin expression level and possibly haptoglobin function. We hypothesised that the CNV associates with long-term outcome beyond the first year after aSAH.