The History of Target-Controlled Infusion

Publikation

The History of Target-Controlled Infusion

Wissenschaftlicher Artikel/Review - 01.01.2016

Struys Michel M R F, De Smet Tom, Glen John Iain B, Vereecke Hugo E M, Absalom Anthony R, Schnider Thomas

Zitation

Struys M, De Smet T, Glen J, Vereecke H, Absalom A, Schnider T. The History of Target-Controlled Infusion. Anesth Analg 2016; 122:56-69.

Art

Wissenschaftlicher Artikel/Review (Englisch)

Zeitschrift

Anesth Analg 2016; 122

Veröffentlichungsdatum

01.01.2016

eISSN (Online)

1526-7598

Seiten

56-69

Kurzbeschreibung/Zielsetzung

Target-controlled infusion (TCI) is a technique of infusing IV drugs to achieve a user-defined predicted ("target") drug concentration in a specific body compartment or tissue of interest. In this review, we describe the pharmacokinetic principles of TCI, the development of TCI systems, and technical and regulatory issues addressed in prototype development. We also describe the launch of the current clinically available systems.