Publication

The History of Target-Controlled Infusion

Journal Paper/Review - Jan 1, 2016

Units
PubMed
Doi

Citation
Struys M, De Smet T, Glen J, Vereecke H, Absalom A, Schnider T. The History of Target-Controlled Infusion. Anesth Analg 2016; 122:56-69.
Type
Journal Paper/Review (English)
Journal
Anesth Analg 2016; 122
Publication Date
Jan 1, 2016
Issn Electronic
1526-7598
Pages
56-69
Brief description/objective

Target-controlled infusion (TCI) is a technique of infusing IV drugs to achieve a user-defined predicted ("target") drug concentration in a specific body compartment or tissue of interest. In this review, we describe the pharmacokinetic principles of TCI, the development of TCI systems, and technical and regulatory issues addressed in prototype development. We also describe the launch of the current clinically available systems.