Publication
The History of Target-Controlled Infusion
Journal Paper/Review - Jan 1, 2016
Struys Michel M R F, De Smet Tom, Glen John Iain B, Vereecke Hugo E M, Absalom Anthony R, Schnider Thomas
Units
PubMed
Doi
Citation
Type
Journal
Publication Date
Issn Electronic
Pages
Brief description/objective
Target-controlled infusion (TCI) is a technique of infusing IV drugs to achieve a user-defined predicted ("target") drug concentration in a specific body compartment or tissue of interest. In this review, we describe the pharmacokinetic principles of TCI, the development of TCI systems, and technical and regulatory issues addressed in prototype development. We also describe the launch of the current clinically available systems.