Risk of colorectal cancer in men on long-term androgen deprivation therapy for prostate cancer

Publikation

Risk of colorectal cancer in men on long-term androgen deprivation therapy for prostate cancer

Wissenschaftlicher Artikel/Review - 10.11.2010

Gillessen Sommer Silke, Templeton Arnoud, Marra Giancarlo, Kuo Yong-Fang, Valtorta Emanuele, Shahinian Vahakn B

Zitation

Gillessen Sommer S, Templeton A, Marra G, Kuo Y, Valtorta E, Shahinian V. Risk of colorectal cancer in men on long-term androgen deprivation therapy for prostate cancer. J Natl Cancer Inst 2010; 102:1760-70.

Art

Wissenschaftlicher Artikel/Review (Englisch)

Zeitschrift

J Natl Cancer Inst 2010; 102

Veröffentlichungsdatum

10.11.2010

eISSN (Online)

1460-2105

Seiten

1760-70

Kurzbeschreibung/Zielsetzung

Androgen deprivation with gonadotropin-releasing hormone (GnRH) agonists or orchiectomy is a common but controversial treatment for prostate cancer. Uncertainties remain about its use, particularly with increasing recognition of serious side effects. In animal studies, androgens protect against colonic carcinogenesis, suggesting that androgen deprivation may increase the risk of colorectal cancer.