Publikation
Risk of colorectal cancer in men on long-term androgen deprivation therapy for prostate cancer
Wissenschaftlicher Artikel/Review - 10.11.2010
Gillessen Sommer Silke, Templeton Arnoud, Marra Giancarlo, Kuo Yong-Fang, Valtorta Emanuele, Shahinian Vahakn B
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Androgen deprivation with gonadotropin-releasing hormone (GnRH) agonists or orchiectomy is a common but controversial treatment for prostate cancer. Uncertainties remain about its use, particularly with increasing recognition of serious side effects. In animal studies, androgens protect against colonic carcinogenesis, suggesting that androgen deprivation may increase the risk of colorectal cancer.