Risk of colorectal cancer in men on long-term androgen deprivation therapy for prostate cancer

Publication

Risk of colorectal cancer in men on long-term androgen deprivation therapy for prostate cancer

Journal Paper/Review - Nov 10, 2010

Gillessen Sommer Silke, Templeton Arnoud, Marra Giancarlo, Kuo Yong-Fang, Valtorta Emanuele, Shahinian Vahakn B

Citation

Gillessen Sommer S, Templeton A, Marra G, Kuo Y, Valtorta E, Shahinian V. Risk of colorectal cancer in men on long-term androgen deprivation therapy for prostate cancer. J Natl Cancer Inst 2010; 102:1760-70.

Type

Journal Paper/Review (English)

Journal

J Natl Cancer Inst 2010; 102

Publication Date

Nov 10, 2010

Issn Electronic

1460-2105

Pages

1760-70

Brief description/objective

Androgen deprivation with gonadotropin-releasing hormone (GnRH) agonists or orchiectomy is a common but controversial treatment for prostate cancer. Uncertainties remain about its use, particularly with increasing recognition of serious side effects. In animal studies, androgens protect against colonic carcinogenesis, suggesting that androgen deprivation may increase the risk of colorectal cancer.