Publikation

Prominent role of KCa3.1 in endothelium-derived hyperpolarizing factor-type dilations and conducted responses in the microcirculation in vivo.

Wissenschaftlicher Artikel/Review - 13.02.2009

Bereiche
PubMed
DOI
Kontakt

Zitation
Wölfle S, Schmidt V, Hoyer J, Köhler R, de Wit C. Prominent role of KCa3.1 in endothelium-derived hyperpolarizing factor-type dilations and conducted responses in the microcirculation in vivo. Cardiovasc Res 2009; 82:476-83.
Art
Wissenschaftlicher Artikel/Review (Englisch)
Zeitschrift
Cardiovasc Res 2009; 82
Veröffentlichungsdatum
13.02.2009
eISSN (Online)
1755-3245
Seiten
476-83
Kurzbeschreibung/Zielsetzung

The activation of endothelial Ca2+-dependent K+-channels, KCa3.1 (IKCa), and KCa2.3 (SKCa) has been proposed to be a prerequisite for endothelial hyperpolarization, which subsequently hyperpolarizes and relaxes smooth muscle [endothelium-derived hyperpolarizing factor (EDHF)-type dilation] and initiates conducted dilations. Although EDHF is the main mediator of acetylcholine (ACh)-induced dilation in the murine skeletal microcirculation, the differential contribution of KCa3.1 and KCa2.3 is not known.