Prominent role of KCa3.1 in endothelium-derived hyperpolarizing factor-type dilations and conducted responses in the microcirculation in vivo.

Publication

Prominent role of KCa3.1 in endothelium-derived hyperpolarizing factor-type dilations and conducted responses in the microcirculation in vivo.

Journal Paper/Review - Feb 13, 2009

Wölfle Stephanie E, Schmidt Volker, Hoyer Joachim, Köhler Ralf, de Wit Cor

Citation

Wölfle S, Schmidt V, Hoyer J, Köhler R, de Wit C. Prominent role of KCa3.1 in endothelium-derived hyperpolarizing factor-type dilations and conducted responses in the microcirculation in vivo. Cardiovasc Res 2009; 82:476-83.

Type

Journal Paper/Review (English)

Journal

Cardiovasc Res 2009; 82

Publication Date

Feb 13, 2009

Issn Electronic

1755-3245

Pages

476-83

Brief description/objective

The activation of endothelial Ca2+-dependent K+-channels, KCa3.1 (IKCa), and KCa2.3 (SKCa) has been proposed to be a prerequisite for endothelial hyperpolarization, which subsequently hyperpolarizes and relaxes smooth muscle [endothelium-derived hyperpolarizing factor (EDHF)-type dilation] and initiates conducted dilations. Although EDHF is the main mediator of acetylcholine (ACh)-induced dilation in the murine skeletal microcirculation, the differential contribution of KCa3.1 and KCa2.3 is not known.