Prominent role of KCa3.1 in endothelium-derived hyperpolarizing factor-type dilations and conducted responses in the microcirculation in vivo.

Publikation

Prominent role of KCa3.1 in endothelium-derived hyperpolarizing factor-type dilations and conducted responses in the microcirculation in vivo.

Wissenschaftlicher Artikel/Review - 13.02.2009

Wölfle Stephanie E, Schmidt Volker, Hoyer Joachim, Köhler Ralf, de Wit Cor

Zitation

Wölfle S, Schmidt V, Hoyer J, Köhler R, de Wit C. Prominent role of KCa3.1 in endothelium-derived hyperpolarizing factor-type dilations and conducted responses in the microcirculation in vivo. Cardiovasc Res 2009; 82:476-83.

Art

Wissenschaftlicher Artikel/Review (Englisch)

Zeitschrift

Cardiovasc Res 2009; 82

Veröffentlichungsdatum

13.02.2009

eISSN (Online)

1755-3245

Seiten

476-83

Kurzbeschreibung/Zielsetzung

The activation of endothelial Ca2+-dependent K+-channels, KCa3.1 (IKCa), and KCa2.3 (SKCa) has been proposed to be a prerequisite for endothelial hyperpolarization, which subsequently hyperpolarizes and relaxes smooth muscle [endothelium-derived hyperpolarizing factor (EDHF)-type dilation] and initiates conducted dilations. Although EDHF is the main mediator of acetylcholine (ACh)-induced dilation in the murine skeletal microcirculation, the differential contribution of KCa3.1 and KCa2.3 is not known.