Publikation

Fat Grafts Show Higher Hypoxia, Angiogenesis, Adipocyte Proliferation, and Macrophage Infiltration than Flaps in a Pilot Mouse Study.

Wissenschaftlicher Artikel/Review - 03.01.2023

Bereiche
PubMed
DOI
Kontakt

Zitation
Thomas B, Warszawski J, Falkner F, Bleichert S, Haug V, Bigdeli A, Schulte M, Hoffmann S, Garvalov B, Schreiber C, Takamiya M, Sleeman J, Schmidt V, Kneser U, Pichler B, Dimmler A, Thiele W. Fat Grafts Show Higher Hypoxia, Angiogenesis, Adipocyte Proliferation, and Macrophage Infiltration than Flaps in a Pilot Mouse Study. Plast Reconstr Surg 2023; 152:96e-109e.
Art
Wissenschaftlicher Artikel/Review (Englisch)
Zeitschrift
Plast Reconstr Surg 2023; 152
Veröffentlichungsdatum
03.01.2023
eISSN (Online)
1529-4242
Seiten
96e-109e
Kurzbeschreibung/Zielsetzung

Over 137,000 breast reconstructions are performed annually by American Society of Plastic Surgeons (ASPS) members. Vascularized flaps and avascular lipofilling each account for over 33,000 autologous reconstructions. Although clinical and experimental observations suggest biologic differences with diverging effects on locoregional tumor control, comparative animal models are lacking. The authors standardized existing techniques in immunocompetent mice, laying the foundation for in vivo models of autologous breast reconstruction combinable with orthotopic tumor implantations.