Fat Grafts Show Higher Hypoxia, Angiogenesis, Adipocyte Proliferation, and Macrophage Infiltration than Flaps in a Pilot Mouse Study.

Publikation

Fat Grafts Show Higher Hypoxia, Angiogenesis, Adipocyte Proliferation, and Macrophage Infiltration than Flaps in a Pilot Mouse Study.

Wissenschaftlicher Artikel/Review - 03.01.2023

Thomas Benjamin, Warszawski Jan, Falkner Florian, Bleichert Sonja, Haug Valentin, Bigdeli Amir Khosrow, Schulte Matthias, Hoffmann Sabrina Hl, Garvalov Boyan K, Schreiber Caroline, Takamiya Masanari, Sleeman Jonathan P, Schmidt Volker, Kneser Ulrich, Pichler Bernd, Dimmler Arno, Thiele Wilko

Zitation

Thomas B, Warszawski J, Falkner F, Bleichert S, Haug V, Bigdeli A, Schulte M, Hoffmann S, Garvalov B, Schreiber C, Takamiya M, Sleeman J, Schmidt V, Kneser U, Pichler B, Dimmler A, Thiele W. Fat Grafts Show Higher Hypoxia, Angiogenesis, Adipocyte Proliferation, and Macrophage Infiltration than Flaps in a Pilot Mouse Study. Plast Reconstr Surg 2023; 152:96e-109e.

Art

Wissenschaftlicher Artikel/Review (Englisch)

Zeitschrift

Plast Reconstr Surg 2023; 152

Veröffentlichungsdatum

03.01.2023

eISSN (Online)

1529-4242

Seiten

96e-109e

Kurzbeschreibung/Zielsetzung

Over 137,000 breast reconstructions are performed annually by American Society of Plastic Surgeons (ASPS) members. Vascularized flaps and avascular lipofilling each account for over 33,000 autologous reconstructions. Although clinical and experimental observations suggest biologic differences with diverging effects on locoregional tumor control, comparative animal models are lacking. The authors standardized existing techniques in immunocompetent mice, laying the foundation for in vivo models of autologous breast reconstruction combinable with orthotopic tumor implantations.