Publication

Fat Grafts Show Higher Hypoxia, Angiogenesis, Adipocyte Proliferation, and Macrophage Infiltration than Flaps in a Pilot Mouse Study.

Journal Paper/Review - Jan 3, 2023

Units
PubMed
Doi
Contact

Citation
Thomas B, Warszawski J, Falkner F, Bleichert S, Haug V, Bigdeli A, Schulte M, Hoffmann S, Garvalov B, Schreiber C, Takamiya M, Sleeman J, Schmidt V, Kneser U, Pichler B, Dimmler A, Thiele W. Fat Grafts Show Higher Hypoxia, Angiogenesis, Adipocyte Proliferation, and Macrophage Infiltration than Flaps in a Pilot Mouse Study. Plast Reconstr Surg 2023; 152:96e-109e.
Type
Journal Paper/Review (English)
Journal
Plast Reconstr Surg 2023; 152
Publication Date
Jan 3, 2023
Issn Electronic
1529-4242
Pages
96e-109e
Brief description/objective

Over 137,000 breast reconstructions are performed annually by American Society of Plastic Surgeons (ASPS) members. Vascularized flaps and avascular lipofilling each account for over 33,000 autologous reconstructions. Although clinical and experimental observations suggest biologic differences with diverging effects on locoregional tumor control, comparative animal models are lacking. The authors standardized existing techniques in immunocompetent mice, laying the foundation for in vivo models of autologous breast reconstruction combinable with orthotopic tumor implantations.