Genetic variation in NFE2L2 is associated with outcome following aneurysmal subarachnoid haemorrhage.

Publikation

Genetic variation in NFE2L2 is associated with outcome following aneurysmal subarachnoid haemorrhage.

Wissenschaftlicher Artikel/Review - 02.10.2022

Gaastra Benjamin, Duncan Poppy, Bakker Mark K, Hostettler Isabel, Alg Varinder S, Houlden Henry, Ruigrok Ynte M, Galea Ian, Tapper Will, Werring David J, Bulters Diederik

Zitation

Gaastra B, Duncan P, Bakker M, Hostettler I, Alg V, Houlden H, Ruigrok Y, Galea I, Tapper W, Werring D, Bulters D. Genetic variation in NFE2L2 is associated with outcome following aneurysmal subarachnoid haemorrhage. Eur J Neurol 2022; 30:116-124.

Art

Wissenschaftlicher Artikel/Review (Englisch)

Zeitschrift

Eur J Neurol 2022; 30

Veröffentlichungsdatum

02.10.2022

eISSN (Online)

1468-1331

Seiten

116-124

Kurzbeschreibung/Zielsetzung

Nuclear factor erythroid 2-related factor 2 (NRF2; encoded by the NFE2L2 gene) has been implicated in outcome following aneurysmal subarachnoid haemorrhage (aSAH) through its activity as a regulator of inflammation, oxidative injury and blood breakdown product clearance. The aim of this study was to identify whether genetic variation in NFE2L2 is associated with clinical outcome following aSAH.