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Genetic variation in NFE2L2 is associated with outcome following aneurysmal subarachnoid haemorrhage.

Journal Paper/Review - Sep 23, 2022

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Citation
Gaastra B, Werring D, Tapper W, Galea I, Ruigrok Y, Houlden H, Alg V, Hostettler I, Bakker M, Duncan P, Bulters D. Genetic variation in NFE2L2 is associated with outcome following aneurysmal subarachnoid haemorrhage.. Eur J Neurol 2022
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Journal Paper/Review (English)
Journal
Eur J Neurol 2022
Publication Date
Sep 23, 2022
Issn Print
Issn Electronic
1468-1331
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Brief description/objective

Nuclear factor erythroid 2-related factor 2 (NRF2; encoded by the NFE2L2 gene) has been implicated in outcome following aneurysmal subarachnoid haemorrhage (aSAH) through its activity as a regulator of inflammation, oxidative injury and blood breakdown product clearance. The aim of this study was to identify whether genetic variation in NFE2L2 is associated with clinical outcome following aSAH.