Genetic variation in NFE2L2 is associated with outcome following aneurysmal subarachnoid haemorrhage.
Journal Paper/Review - Sep 23, 2022
Gaastra Ben, Werring David, Tapper Will, Galea Ian, Ruigrok Ynte M, Houlden Henry, Alg Varinder S, Hostettler Isabel, Bakker Mark K, Duncan Poppy, Bulters Diederik
Nuclear factor erythroid 2-related factor 2 (NRF2; encoded by the NFE2L2 gene) has been implicated in outcome following aneurysmal subarachnoid haemorrhage (aSAH) through its activity as a regulator of inflammation, oxidative injury and blood breakdown product clearance. The aim of this study was to identify whether genetic variation in NFE2L2 is associated with clinical outcome following aSAH.