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Axillary lymph nodes are often metastatic sites of primary breast cancer and are a major prognostic factor. No reliable non-invasive technique is available for detection of lymph node metastases. In most cases, Level I nodes (below pectoralis minor) are involved first: “skip” metastases to higher levels without Level I involvement are rare. The risk of metastasis correlates directly with the size of the primary tumor. When the primary tumor is less than 1 cm in diameter, the risk of axillary metastasis is about 10%; when it is greater than 5 cm, the risk increases to more than 70%.