A randomized trial of axillary dissection versus no axillary dissection for patients with clinically node negative breast cancer and micrometastases in the sentinel node

Project

A randomized trial of axillary dissection versus no axillary dissection for patients with clinically node negative breast cancer and micrometastases in the sentinel node

Automatically Closed · 2003 until 2010

Kehl Jeanine

Type

Clinical Studies

Range

Multicentric, KSSG as participating partner

Units

Medizinische Onkologie und Hämatologie

Status

Automatically Closed

Start Date

2003

End Date

2010

Study Design

a multi-national, randomized clinical trial

Keywords

low- dose chemotherapy regimen

Partner

Dr. Viviana Galimberti, Milano, Italia Dr. Stefano Zurrida Prof. U. Veronesi

Brief description/objective

Axillary lymph nodes are often metastatic sites of primary breast cancer and are a major prognostic factor. No reliable non-invasive technique is available for detection of lymph node metastases. In most cases, Level I nodes (below pectoralis minor) are involved first: “skip” metastases to higher levels without Level I involvement are rare. The risk of metastasis correlates directly with the size of the primary tumor. When the primary tumor is less than 1 cm in diameter, the risk of axillary metastasis is about 10%; when it is greater than 5 cm, the risk increases to more than 70%.