The Neuroprotective Effect of Lamotrigine and Interferon Beta 1a in Patients With Relapsing-Remitting Multiple Sclerosis

Projekt

The Neuroprotective Effect of Lamotrigine and Interferon Beta 1a in Patients With Relapsing-Remitting Multiple Sclerosis

Automatisch geschlossen · 2009 bis 2011

Putzki Norman, Yildiz Murat, Müller Anna, Siebel Philip

Art

Klinische Forschung

Reichweite

Monozentrisch am KSSG

Bereiche

Neurologie

Status

Automatisch geschlossen

Start

2009

Ende

2011

Finanzierungsart

Industrie

Studiendesign

randomized, placebo-controlled, MRI rater blinded study

Schlagwörter (Tags)

MS, neuroprotection, phase II, interferon-beta

Webseite

http://clinicaltrials.gov/ct2/show/NCT00917839

Kurzbeschreibung/Zielsetzung

Randomized, Placebo-Controlled Phase II Monocentric Trial for the Neuroprotective Effect of Lamotrigine Plus Interferon Beta 1a 30mcg Once Weekly Intramuscular in Patients With Relapsing-Remitting Multiple Sclerosis.

Primary Outcome Measures:
N-Acetyl-Aspartate / creatine - quotient in normal appearing white matter by MR-spectroscopy [ Time Frame: 12 months ]
Safety of lamotrigine in combination with interferon beta 1a (30 mcg) once weekly intramuscular. [ Time Frame: 6 months, 12 months ]