Projekt

Shunt-dependency after aneurysmal subarachnoid haemorrhage – the role of early hyperglycaemia in cerebro-spinal fluid and blood

Laufend - Rekrutierung – laufend · 2024 bis 2027

Art
Klinische Forschung
Reichweite
Multizentrisch, KSSG als Hauptzentrum
Bereiche
Status
Laufend - Rekrutierung – laufend
Start
2024
Ende
2027
Finanzierungsart
Fördermittel KSSG
Studiendesign
Prospective, cohort, multicentre study (Canton Hospital St. Gallen, Canton Hospital Aarau, University Hospital Basel)
Schlagwörter (Tags)
aneurysmal subarachnoid haemorrhage hyperglycaemia hydrocephalus ventriculo-peritoneal shunt extra-ventricular drain lumbar drain
Kurzbeschreibung/Zielsetzung

Several factors influence morbidity after aneurysmal subarachnoid haemorrhage (aSAH) and therefore also functional outcome. One of these factors is hydrocephalus (HCP) which, in case of unsuccessful weaning from an extraventricular drain (EVD) can lead to ventriculo-peritoneal shunt (VPS) dependency opening further possible complications and therefore increased morbidity. Our aim is to confirm the association of early increased glucose levels in cerebro-spinal fluid (CSF) and VPS-dependency also evaluating the influence of blood glucose on VPS dependency in patients suffering from an aSAH. By confirming, or contradicting, previous findings we aim to finally answer the question about association of hyperglycaemia and VPS-dependency as well as the importance of at which time point elevated glucose levels influence this. This would have clear implications on future clinical management as if hyperglycaemia is indeed established as an influencing factor on VPS dependency this could provide us with a potential target by influencing glucose levels and could lead to early VPS placement instead of repeated EVD replacements. By doing so morbidity could be reduced.